Rest and rinse: sleeping rhythms drive brain detox

Leon C.D. Smyth; Benjamin A. Plog; Jonathan Kipnis

doi:10.1016/j.it.2025.02.007

Rest and rinse: sleeping rhythms drive brain detox

Leon C.D. Smyth, Benjamin A. Plog, Jonathan Kipnis

Research output: Contribution to journal › Short survey › peer-review

Abstract

Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

Original language	English
Pages (from-to)	189-191
Number of pages	3
Journal	Trends in Immunology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.it.2025.02.007
State	Published - Mar 2025

Access to Document

10.1016/j.it.2025.02.007

Cite this

@article{eb577c52574547b386384a647b6fecbc,

title = "Rest and rinse: sleeping rhythms drive brain detox",

abstract = "Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.",

author = "Smyth, {Leon C.D.} and Plog, {Benjamin A.} and Jonathan Kipnis",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s)",

year = "2025",

month = mar,

doi = "10.1016/j.it.2025.02.007",

language = "English",

volume = "46",

pages = "189--191",

journal = "Trends in Immunology",

issn = "1471-4906",

number = "3",

}

TY - JOUR

T1 - Rest and rinse

T2 - sleeping rhythms drive brain detox

AU - Smyth, Leon C.D.

AU - Plog, Benjamin A.

AU - Kipnis, Jonathan

PY - 2025/3

Y1 - 2025/3

N2 - Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

AB - Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

UR - http://www.scopus.com/inward/record.url?scp=85219157489&partnerID=8YFLogxK

U2 - 10.1016/j.it.2025.02.007

DO - 10.1016/j.it.2025.02.007

M3 - Short survey

C2 - 40023739

AN - SCOPUS:85219157489

SN - 1471-4906

VL - 46

SP - 189

EP - 191

JO - Trends in Immunology

JF - Trends in Immunology

IS - 3

ER -

Rest and rinse: sleeping rhythms drive brain detox

Abstract

Access to Document

Other files and links

Fingerprint

Cite this