TY - JOUR
T1 - Responsive neurostimulation for focal motor status epilepticus
AU - Yang, Jimmy C.
AU - Harid, Nitish M.
AU - Nascimento, Fábio A.
AU - Kokkinos, Vasileios
AU - Shaughnessy, Abigail
AU - Lam, Alice D.
AU - Westover, M. Brandon
AU - Leslie-Mazwi, Thabele M.
AU - Hochberg, Leigh R.
AU - Rosenthal, Eric S.
AU - Cole, Andrew J.
AU - Richardson, Robert M.
AU - Cash, Sydney S.
N1 - Funding Information:
No funding source. We thank Daniel J. Soper and Alexander Zhang for their assistance with 3D reconstruction generation; Kara Houghton, Brendan Thomas, Kristy Nordstrom, and Fausto Minido for their technological assistance in the Epilepsy Monitoring Unit; the nurses, fellows, residents, and patient care staff of the MGH Neuroscience Intensive Care Unit and Inpatient Floor for their expert care; Michael Nozzolillo and Wendy Wan for their RNS technological assistance; and Nora Daly for her clinical assistance.
Publisher Copyright:
© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association
PY - 2021/6
Y1 - 2021/6
N2 - No clear evidence-based treatment paradigm currently exists for refractory and super-refractory status epilepticus, which can result in significant mortality and morbidity. While patients are typically treated with antiepileptic drugs and anesthetics, neurosurgical neuromodulation techniques can also be considered. We present a novel case in which responsive neurostimulation was used to effectively treat a patient who had developed super-refractory status epilepticus, later consistent with epilepsia partialis continua, that was refractory to antiepileptic drugs, immunomodulatory therapies, and transcranial magnetic stimulation. This case demonstrates how regional therapy provided by responsive neurostimulation can be effective in treating super-refractory status epilepticus through neuromodulation of seizure networks.
AB - No clear evidence-based treatment paradigm currently exists for refractory and super-refractory status epilepticus, which can result in significant mortality and morbidity. While patients are typically treated with antiepileptic drugs and anesthetics, neurosurgical neuromodulation techniques can also be considered. We present a novel case in which responsive neurostimulation was used to effectively treat a patient who had developed super-refractory status epilepticus, later consistent with epilepsia partialis continua, that was refractory to antiepileptic drugs, immunomodulatory therapies, and transcranial magnetic stimulation. This case demonstrates how regional therapy provided by responsive neurostimulation can be effective in treating super-refractory status epilepticus through neuromodulation of seizure networks.
UR - http://www.scopus.com/inward/record.url?scp=85105164603&partnerID=8YFLogxK
U2 - 10.1002/acn3.51318
DO - 10.1002/acn3.51318
M3 - Article
C2 - 33955717
AN - SCOPUS:85105164603
SN - 2328-9503
VL - 8
SP - 1353
EP - 1361
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 6
ER -