Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

Bhavna Kumar; Kitrina G. Cordell; Julia S. Lee; Mark E. Prince; Huong H. Tran; Gregory T. Wolf; Susan G. Urba; Francis P. Worden; Douglas B. Chepeha; Theodoros N. Teknos; Avraham Eisbruch; Christina I. Tsien; Jeremy M.G. Taylor; Nisha J. D'Silva; Kun Yang; David M. Kurnit; Carol R. Bradford; Thomas E. Carey

doi:10.1016/j.ijrobp.2007.05.072

Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

Bhavna Kumar, Kitrina G. Cordell, Julia S. Lee, Mark E. Prince, Huong H. Tran, Gregory T. Wolf, Susan G. Urba, Francis P. Worden, Douglas B. Chepeha, Theodoros N. Teknos, Avraham Eisbruch, Christina I. Tsien, Jeremy M.G. Taylor, Nisha J. D'Silva, Kun Yang, David M. Kurnit, Carol R. Bradford, Thomas E. Carey

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.

Original language	English
Pages (from-to)	S109-S111
Journal	International Journal of Radiation Oncology Biology Physics
Volume	69
Issue number	2 SUPPL.
DOIs	https://doi.org/10.1016/j.ijrobp.2007.05.072
State	Published - Oct 1 2007

Keywords

Chemoradiation
Epidermal growth factor receptor
High risk human papillomavirus
Organ sparing clinical trial
Tonsil cancer

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10.1016/j.ijrobp.2007.05.072

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Kumar, B., Cordell, K. G., Lee, J. S., Prince, M. E., Tran, H. H., Wolf, G. T., Urba, S. G., Worden, F. P., Chepeha, D. B., Teknos, T. N., Eisbruch, A., Tsien, C. I., Taylor, J. M. G., D'Silva, N. J., Yang, K., Kurnit, D. M., Bradford, C. R., & Carey, T. E. (2007). Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking. International Journal of Radiation Oncology Biology Physics, 69(2 SUPPL.), S109-S111. https://doi.org/10.1016/j.ijrobp.2007.05.072

@article{1a86e48e0ae44211999de3afdee3d01c,

title = "Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking",

abstract = "Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.",

keywords = "Chemoradiation, Epidermal growth factor receptor, High risk human papillomavirus, Organ sparing clinical trial, Tonsil cancer",

author = "Bhavna Kumar and Cordell, {Kitrina G.} and Lee, {Julia S.} and Prince, {Mark E.} and Tran, {Huong H.} and Wolf, {Gregory T.} and Urba, {Susan G.} and Worden, {Francis P.} and Chepeha, {Douglas B.} and Teknos, {Theodoros N.} and Avraham Eisbruch and Tsien, {Christina I.} and Taylor, {Jeremy M.G.} and D'Silva, {Nisha J.} and Kun Yang and Kurnit, {David M.} and Bradford, {Carol R.} and Carey, {Thomas E.}",

note = "Funding Information: Supported by NIH NIDCR (R01 DE13346) & NIDCD (P30 DC 05188), NIH NCI (R01 CA83087), and University of Michigan's Head and Neck Cancer SPORE grant (P50 CA97248) and Cancer Center Support Grant (P30 CA46592). ",

year = "2007",

month = oct,

day = "1",

doi = "10.1016/j.ijrobp.2007.05.072",

language = "English",

volume = "69",

pages = "S109--S111",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

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Kumar, B, Cordell, KG, Lee, JS, Prince, ME, Tran, HH, Wolf, GT, Urba, SG, Worden, FP, Chepeha, DB, Teknos, TN, Eisbruch, A, Tsien, CI, Taylor, JMG, D'Silva, NJ, Yang, K, Kurnit, DM, Bradford, CR & Carey, TE 2007, 'Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking', International Journal of Radiation Oncology Biology Physics, vol. 69, no. 2 SUPPL., pp. S109-S111. https://doi.org/10.1016/j.ijrobp.2007.05.072

Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking. / Kumar, Bhavna; Cordell, Kitrina G.; Lee, Julia S. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 69, No. 2 SUPPL., 01.10.2007, p. S109-S111.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

AU - Kumar, Bhavna

AU - Cordell, Kitrina G.

AU - Lee, Julia S.

AU - Prince, Mark E.

AU - Tran, Huong H.

AU - Wolf, Gregory T.

AU - Urba, Susan G.

AU - Worden, Francis P.

AU - Chepeha, Douglas B.

AU - Teknos, Theodoros N.

AU - Eisbruch, Avraham

AU - Tsien, Christina I.

AU - Taylor, Jeremy M.G.

AU - D'Silva, Nisha J.

AU - Yang, Kun

AU - Kurnit, David M.

AU - Bradford, Carol R.

AU - Carey, Thomas E.

N1 - Funding Information: Supported by NIH NIDCR (R01 DE13346) & NIDCD (P30 DC 05188), NIH NCI (R01 CA83087), and University of Michigan's Head and Neck Cancer SPORE grant (P50 CA97248) and Cancer Center Support Grant (P30 CA46592).

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.

AB - Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.

KW - Chemoradiation

KW - Epidermal growth factor receptor

KW - High risk human papillomavirus

KW - Organ sparing clinical trial

KW - Tonsil cancer

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U2 - 10.1016/j.ijrobp.2007.05.072

DO - 10.1016/j.ijrobp.2007.05.072

M3 - Article

C2 - 17848274

AN - SCOPUS:34548417668

SN - 0360-3016

VL - 69

SP - S109-S111

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 2 SUPPL.

ER -

Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

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Keywords

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