Response to Comment on "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women"

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Abstract

In evaluating any randomized clinical trial, it is important to determine whether baseline differences between groups could have affected the primary outcome. In our study, muscle insulin sensitivity, which was identical in both groups at baseline, improved after nicotinamide mononucleotide (NMN), not placebo, therapy. Differences in baseline intrahepatic triglyceride content between groups do not negate the effects of NMN observed in muscle.

Original languageEnglish
Article numbereabj7375
JournalScience
Volume373
Issue number6554
DOIs
StatePublished - Jul 30 2021

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