TY - JOUR
T1 - Response to bortezomib (velcade) in a case of advanced bronchiolo-alveolar carcinoma (BAC)
T2 - A case report
AU - Subramanian, Janakiraman
AU - Pillot, Giancarlo
AU - Narra, Vamsidhar
AU - Govindan, Ramaswamy
PY - 2006/2
Y1 - 2006/2
N2 - A 65-year-old male with 40-pack year smoking history presented with exertional dyspnea and was subsequently diagnosed with bronchiolo-alveolar carcinoma (BAC). He did not respond to first line therapy with geftinib, but he achieved disease stabilization with gemcitabine and carboplatin for 4 months before developing symptomatic worsening requiring oxygen supplementation. He responded dramatically to bortezomib with rapid symptom improvement. The follow-up computerized tomography revealed partial response that was maintained for 11 months. Based on observations like this and those seen in phase I studies with bortezomib, this agent is being studied now in patients with bronchio-alevolar cancer.
AB - A 65-year-old male with 40-pack year smoking history presented with exertional dyspnea and was subsequently diagnosed with bronchiolo-alveolar carcinoma (BAC). He did not respond to first line therapy with geftinib, but he achieved disease stabilization with gemcitabine and carboplatin for 4 months before developing symptomatic worsening requiring oxygen supplementation. He responded dramatically to bortezomib with rapid symptom improvement. The follow-up computerized tomography revealed partial response that was maintained for 11 months. Based on observations like this and those seen in phase I studies with bortezomib, this agent is being studied now in patients with bronchio-alevolar cancer.
KW - Bortezomib
KW - Bronchiolo-alveolar carcinoma
KW - Non-small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=31344440016&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2005.10.007
DO - 10.1016/j.lungcan.2005.10.007
M3 - Article
C2 - 16387387
AN - SCOPUS:31344440016
SN - 0169-5002
VL - 51
SP - 257
EP - 259
JO - Lung Cancer
JF - Lung Cancer
IS - 2
ER -