@article{e2f81f2b212b447f939082b801564772,
title = "Response to antiseizure medications in neonates with acute symptomatic seizures",
abstract = "In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.",
keywords = "AED, antiepileptic drug, electroencephalogram, epilepsy, hypoxic-ischemic encephalopathy, neonatal encephalopathy, neonatal seizures, neurocritical care, seizure",
author = "{the Neonatal Seizure Registry Study Group} and Glass, {Hannah C.} and Soul, {Janet S.} and Chu, {Catherine J.} and Massey, {Shavonne L.} and Wusthoff, {Courtney J.} and Taeun Chang and Cilio, {Maria Roberta} and Bonifacio, {Sonia L.} and Abend, {Nicholas S.} and Cameron Thomas and Monica Lemmon and McCulloch, {Charles E.} and Shellhaas, {Ren{\'e}e A.}",
note = "Funding Information: The Pediatric Epilepsy Research Foundation and the Patient Centered Outcomes Research Institute supported this study but did not participate in design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. The authors thank Drs Donna Ferriero and Faye Silverstein for their contributions to the NSR, as well as the research assistants and parent partners at each study site. Funding Information: J.S.S. receives royalties from UpToDate. C.J.W. has served as a paid consultant for Ceribell and Persyst. M.R.C. received research funding from Insys Development Company, paid to her Institution, for company sponsored trials; she has been a consultant for BioMarin Research and for GW Pharmaceuticals. R.A.S. is a consultant for the Epilepsy Study Consortium and receives honoraria from UpToDate for neonatal seizures topics. None of the other authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Publisher Copyright: Wiley Periodicals, Inc. {\textcopyright} 2019 International League Against Epilepsy",
year = "2019",
month = mar,
doi = "10.1111/epi.14671",
language = "English",
volume = "60",
pages = "e20--e24",
journal = "Epilepsia",
issn = "0013-9580",
number = "3",
}