Abstract
Background and purpose: The need for target adjustment due to respiratory motion variation and the value of carina as a motion surrogate is evaluated for locally advanced non-small-cell lung cancer. Material and methods: Using weekly 4D CTs (with audio-visual biofeedback) of 12 patients, respiratory motion variation of primary tumors (PT), lymph nodes (LN) and carina (C) were determined. Results: Mean (SD) 3D respiratory motion ranges of PT, LN and C were 4 (3), 5 (3) and 5 (3) mm. PT and LN (p = 0.003), and LN and C motion range were correlated (p = 0.03). Only 20%/5% of all scans had variations >3mm/5mm. Large respiratory motion range on the initial scan was associated with larger during-treatment variations for PT (p = 0.03) and LN (p = 0.001). Conclusions: Motion reassessment is recommended in patients with large initial motion range. Relative motion-related displacements between PT and LN were larger than PT and LN motion alone. Both PT and C appear to be comparable surrogates for LN respiratory motion.
Original language | English |
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Article number | 133 |
Journal | Radiation Oncology |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - Jun 14 2015 |
Keywords
- Lymph nodes
- Non-small-cell lung cancer
- Primary tumor
- Respiratory motion