Respiratory and pulmonary complications in head and neck cancer patients: Evidence-based review for the COVID-19 era

Dustin A. Silverman, Chen Lin, Akina Tamaki, Sidharth V. Puram, Ricardo L. Carrau, Nolan B. Seim, Antoine Eskander, James W. Rocco, Matthew O. Old, Stephen Y. Kang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Pulmonary complications and infections frequently affect patients with head and neck squamous cell carcinoma (HNSCC). Common characteristics can predispose these patients to the development of severe respiratory illness, which may be particularly relevant during the 2019 coronavirus disease (COVID-19) pandemic. Methods: A scoping review was performed to assess the impact of pulmonary comorbidities and adverse respiratory outcomes in HNSCC patients. Results: Advanced age, history of tobacco and alcohol abuse, and cardiopulmonary comorbidities are significant risk factors for the development of adverse respiratory outcomes. Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks. Conclusion: Respiratory complications are a frequent cause of morbidity and mortality among HNSCC patients, and the COVID-19 pandemic may disproportionately affect this population. Interventions designed to decrease smoking and alcohol use, improve oral hygiene, and aggressively manage medical comorbidities are important to the long-term management and health of these patients.

Original languageEnglish
Pages (from-to)1218-1226
Number of pages9
JournalHead and Neck
Volume42
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • COVID-19
  • adverse respiratory outcomes
  • head and neck squamous cell carcinoma (HNSCC)
  • pulmonary comorbidities
  • respiratory infections and complications

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