Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient

Steven L. Kelly; David C. Lamb; Mark Taylor; Andrew J. Corran; Brian C. Baldwin; William G. Powderly

doi:10.1111/j.1574-6968.1994.tb07140.x

Resistance to amphotericin B associated with defective sterol Δ^8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient

Steven L. Kelly, David C. Lamb, Mark Taylor, Andrew J. Corran, Brian C. Baldwin, William G. Powderly

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ^8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

Original language	English
Pages (from-to)	39-42
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	122
Issue number	1-2
DOIs	https://doi.org/10.1111/j.1574-6968.1994.tb07140.x
State	Published - Sep 15 1994

Keywords

Amphotericin B
Cryptococcus neoformans
Resistance

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10.1111/j.1574-6968.1994.tb07140.x

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title = "Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient",

abstract = "Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.",

keywords = "Amphotericin B, Cryptococcus neoformans, Resistance",

author = "Kelly, {Steven L.} and Lamb, {David C.} and Mark Taylor and Corran, {Andrew J.} and Baldwin, {Brian C.} and Powderly, {William G.}",

note = "Funding Information: We would like to thank the Wellcome Trust for partial support. One of us (D.C.L.) is a SERC CASE student with Zeneca Agrochemicals.",

year = "1994",

month = sep,

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doi = "10.1111/j.1574-6968.1994.tb07140.x",

language = "English",

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pages = "39--42",

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TY - JOUR

T1 - Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient

AU - Kelly, Steven L.

AU - Lamb, David C.

AU - Taylor, Mark

AU - Corran, Andrew J.

AU - Baldwin, Brian C.

AU - Powderly, William G.

N1 - Funding Information: We would like to thank the Wellcome Trust for partial support. One of us (D.C.L.) is a SERC CASE student with Zeneca Agrochemicals.

PY - 1994/9/15

Y1 - 1994/9/15

N2 - Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

AB - Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

KW - Amphotericin B

KW - Cryptococcus neoformans

KW - Resistance

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U2 - 10.1111/j.1574-6968.1994.tb07140.x

DO - 10.1111/j.1574-6968.1994.tb07140.x

M3 - Article

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AN - SCOPUS:0027956453

SN - 0378-1097

VL - 122

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JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1-2

ER -

Resistance to amphotericin B associated with defective sterol Δ^8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient

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