Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.
|Number of pages||4|
|Journal||FEMS Microbiology Letters|
|State||Published - Sep 15 1994|
- Amphotericin B
- Cryptococcus neoformans