Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient

Steven L. Kelly, David C. Lamb, Mark Taylor, Andrew J. Corran, Brian C. Baldwin, William G. Powderly

Research output: Contribution to journalArticle

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Abstract

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Δ8→7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalFEMS Microbiology Letters
Volume122
Issue number1-2
DOIs
StatePublished - Sep 15 1994

Keywords

  • Amphotericin B
  • Cryptococcus neoformans
  • Resistance

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