Resistance exercise training reduces hypertriglyceridemia in HIV-infected men treated with antiviral therapy

K. E. Yarasheski, P. Tebas, B. Stanerson, S. Claxton, D. Marin, K. Bae, M. Kennedy, W. Tantisiriwat, W. G. Powderly

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Hypertriglyceridemia, peripheral insulin resistance, and trunk adiposity are metabolic complications recently recognized in people infected with human immunodeficiency virus (HIV) and treated with highly active antiretroviral therapy (HAART). These complications may respond favorably to exercise training. Using a paired design, we determined whether 16 wk of weight-lifting exercise increased muscle mass and strength and decreased fasting serum triglycerides and adipose tissue mass in 18 HIV-infected men. The resistance exercise regimen consisted of three upper and four lower body exercises done for 1-1.5 h/day, 4 days/wk for 64 sessions. Dual-energy X-ray absorptiometry indicated that exercise training increased whole body lean mass 1.4 kg (P = 0.005) but did not reduce adipose tissue mass (P = NS). Axial proton-magnetic resonance imaging indicated that thigh muscle cross-sectional area increased 5-7 cm2 (P < 0.005). Muscle strength increased 23-38% (P < 0.0001) on all exercises. Fasting serum triglycerides were decreased at the end of training (281-204 mg/dl; P = 0.02). These findings imply that resistance exercise training-induced muscle hypertrophy may promote triglyceride clearance from the circulation of hypertriglyceridemic HIV-infected men treated with antiviral therapy.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Applied Physiology
Volume90
Issue number1
DOIs
StatePublished - 2001

Keywords

  • AIDS
  • Lipid metabolism
  • Magnetic resonance imaging
  • Metabolic complications
  • Muscle protein mass
  • Progressive resistance exercise training

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