Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans

Jeffrey S. Greiwe, Cheng Bo, Deborah C. Rubin, Kevin E. Yarasheski, Clay F. Semenkovich

Research output: Contribution to journalArticle

332 Scopus citations

Abstract

Skeletal muscle protein and function decline with advancing age but the underlying pathophysiology is poorly understood. To test the hypothesis that the catabolic cytokine tumor necrosis factor alpha (TNF-α contributes to this process, we studied the effects of aging and resistance exercise on TNF-α expression in human muscle. Using in situ hybridization, TNF-α message was localized to myocytes in sections of skeletal muscle from elderly humans. Both TNF-α mRNA and protein levels were elevated in skeletal muscle from frail elderly (81±1 year) as compared to healthy young (23±1 year) men and women. To determine whether resistance exercise affects TNF-α expression, frail elderly men and women were randomly assigned to a training group or to a nonexercising control group. Muscle biopsies were performed before and after 3 months. Muscle TNF-α mRNA and protein levels decreased in the exercise group but did not change in the control group. Muscle protein synthesis rate in the exercise group was inversely related to levels of TNF-α protein. These data suggest that TNF-α contributes to age-associated muscle wasting and that resistance exercise may attenuate this process by suppressing skeletal muscle TNF-α expression. - Greiwe, J. S., Cheng, B., Rubin, D. C., Yarasheski, K. E., Semenkovich, C. F. Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalFASEB Journal
Volume15
Issue number2
DOIs
StatePublished - Feb 20 2001

Keywords

  • Aging
  • Cytokines
  • Lipoprotein lipase
  • Sarcopenia

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