TY - JOUR
T1 - Resilience, pain, and the brain
T2 - Relationships differ by sociodemographics
AU - Tanner, Jared J.
AU - Johnson, Alisa J.
AU - Terry, Ellen L.
AU - Cardoso, Josue
AU - Garvan, Cynthia
AU - Staud, Roland
AU - Deutsch, Georg
AU - Deshpande, Hrishikesh
AU - Lai, Song
AU - Addison, Adriana
AU - Redden, David
AU - Goodin, Burel R.
AU - Price, Catherine C.
AU - Fillingim, Roger B.
AU - Sibille, Kimberly T.
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/5
Y1 - 2021/5
N2 - Chronic musculoskeletal (MSK) pain is disabling to individuals and burdensome to society. A relationship between telomere length and resilience was reported in individuals with consideration for chronic pain intensity. While chronic pain associates with brain changes, little is known regarding the neurobiological interface of resilience. In a group of individuals with chronic MSK pain, we examined the relationships between a previously investigated resilience index, clinical pain and functioning measures, and pain-related brain structures, with consideration for sex and ethnicity/race. A cross-sectional analysis of 166 non-Hispanic Black and non-Hispanic White adults, 45–85 years of age with pain ≥ 1 body site (s) over the past 3 months was completed. Measures of clinical pain and functioning, biobehavioral and psychosocial resilience, and structural MRI were completed. Our findings indicate higher levels of resilience associate with lower levels of clinical pain and functional limitations. Significant associations between resilience, ethnicity/race, and/or sex, and pain-related brain gray matter structure were demonstrated in the right amygdaloid complex, bilateral thalamus, and postcentral gyrus. Our findings provide compelling evidence that in order to decipher the neurobiological code of chronic pain and related protective factors, it will be important to improve how chronic pain is phenotyped; to include an equal representation of females in studies including analyses stratifying by sex, and to consider other sociodemographic factors.
AB - Chronic musculoskeletal (MSK) pain is disabling to individuals and burdensome to society. A relationship between telomere length and resilience was reported in individuals with consideration for chronic pain intensity. While chronic pain associates with brain changes, little is known regarding the neurobiological interface of resilience. In a group of individuals with chronic MSK pain, we examined the relationships between a previously investigated resilience index, clinical pain and functioning measures, and pain-related brain structures, with consideration for sex and ethnicity/race. A cross-sectional analysis of 166 non-Hispanic Black and non-Hispanic White adults, 45–85 years of age with pain ≥ 1 body site (s) over the past 3 months was completed. Measures of clinical pain and functioning, biobehavioral and psychosocial resilience, and structural MRI were completed. Our findings indicate higher levels of resilience associate with lower levels of clinical pain and functional limitations. Significant associations between resilience, ethnicity/race, and/or sex, and pain-related brain gray matter structure were demonstrated in the right amygdaloid complex, bilateral thalamus, and postcentral gyrus. Our findings provide compelling evidence that in order to decipher the neurobiological code of chronic pain and related protective factors, it will be important to improve how chronic pain is phenotyped; to include an equal representation of females in studies including analyses stratifying by sex, and to consider other sociodemographic factors.
KW - amygdaloid complex
KW - chronic musculoskeletal pain
KW - pain-related brain structure
KW - resilience
KW - sociodemographic factors
UR - http://www.scopus.com/inward/record.url?scp=85100979206&partnerID=8YFLogxK
U2 - 10.1002/jnr.24790
DO - 10.1002/jnr.24790
M3 - Article
C2 - 33606287
AN - SCOPUS:85100979206
SN - 0360-4012
VL - 99
SP - 1207
EP - 1235
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 5
ER -