Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S. Czepielewski; Gwendalyn J. Randolph

doi:10.1016/j.immuni.2023.07.013

Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S. Czepielewski
, Gwendalyn J. Randolph

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

Original language	English
Pages (from-to)	1699-1701
Number of pages	3
Journal	Immunity
Volume	56
Issue number	8
DOIs	https://doi.org/10.1016/j.immuni.2023.07.013
State	Published - Aug 8 2023

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10.1016/j.immuni.2023.07.013

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title = "Resident dendritic cell density in the lymph node paracortex is preDC-estined",

abstract = "Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.",

author = "Czepielewski, \{Rafael S.\} and Randolph, \{Gwendalyn J.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

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doi = "10.1016/j.immuni.2023.07.013",

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AU - Czepielewski, Rafael S.

AU - Randolph, Gwendalyn J.

PY - 2023/8/8

Y1 - 2023/8/8

N2 - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

AB - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

UR - https://www.scopus.com/pages/publications/85166676781

U2 - 10.1016/j.immuni.2023.07.013

DO - 10.1016/j.immuni.2023.07.013

M3 - Comment/debate

C2 - 37557075

AN - SCOPUS:85166676781

SN - 1074-7613

VL - 56

SP - 1699

EP - 1701

JO - Immunity

JF - Immunity

IS - 8

ER -

Resident dendritic cell density in the lymph node paracortex is preDC-estined

Abstract

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