TY - JOUR
T1 - Resident dendritic cell density in the lymph node paracortex is preDC-estined
AU - Czepielewski, Rafael S.
AU - Randolph, Gwendalyn J.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/8/8
Y1 - 2023/8/8
N2 - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.
AB - Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.
UR - http://www.scopus.com/inward/record.url?scp=85166676781&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2023.07.013
DO - 10.1016/j.immuni.2023.07.013
M3 - Comment/debate
C2 - 37557075
AN - SCOPUS:85166676781
SN - 1074-7613
VL - 56
SP - 1699
EP - 1701
JO - Immunity
JF - Immunity
IS - 8
ER -