Resection of pancreatic neuroendocrine tumors: defining patterns and time course of recurrence

Ding Hui Dong, Xu Feng Zhang, Alexandra G. Lopez-Aguiar, George Poultsides, Eleftherios Makris, Flavio Rocha, Zaheer Kanji, Sharon Weber, Alexander Fisher, Ryan Fields, Bradley A. Krasnick, Kamran Idrees, Paula M. Smith, Cliff Cho, Megan Beems, Mary Dillhoff, Shishir K. Maithel, Timothy M. Pawlik

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: To define recurrence patterns and time course, as well as risk factors associated with recurrence following curative resection of pNETs. Method: Patients who underwent curative-intent resection for pNET between 1997 and 2016 were identified from the US Neuroendocrine Tumor Study Group. Data on baseline and tumor-specific characteristics, overall survival (OS), timing and first-site of recurrence, predictors and recurrence management were analyzed. Results: Among 1020 patients, 154 (15.1%) patients developed recurrence. Among patients who experienced recurrence, 76 (49.4%) had liver-only recurrence, while 35 (22.7%) had pancreas-only recurrence. The proportion of liver-only recurrence increased from 54.3% within one-year after surgery to 61.5% from four-to-six years after surgery; whereas the proportion of pancreas-only recurrence decreased from 26.1% to 7.7% over these time periods. While liver-only recurrence was associated with tumor characteristics, pancreas-only recurrence was only associated with surgical margin status. Patients undergoing curative resection of recurrence had comparable OS with patients who had no recurrence (median OS, pancreas-only recurrence, 133.9 months; liver-only recurrence, not attained; no recurrence, 143.0 months, p = 0.499) Conclusions: Different recurrence patterns and timing course, as well as risk factors suggest biological heterogeneity of pNET recurrence. A personalized approach to postoperative surveillance and treatment of recurrence disease should be considered.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalHPB
Volume22
Issue number2
DOIs
StatePublished - Feb 2020

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    Dong, D. H., Zhang, X. F., Lopez-Aguiar, A. G., Poultsides, G., Makris, E., Rocha, F., Kanji, Z., Weber, S., Fisher, A., Fields, R., Krasnick, B. A., Idrees, K., Smith, P. M., Cho, C., Beems, M., Dillhoff, M., Maithel, S. K., & Pawlik, T. M. (2020). Resection of pancreatic neuroendocrine tumors: defining patterns and time course of recurrence. HPB, 22(2), 215-223. https://doi.org/10.1016/j.hpb.2019.05.020