TY - JOUR
T1 - Rescuing Cardiac Cells and Improving Cardiac Function by Targeted Delivery of Oxygen-Releasing Nanoparticles after or even before Acute Myocardial Infarction
AU - Guan, Ya
AU - Niu, Hong
AU - Wen, Jiaxing
AU - Dang, Yu
AU - Zayed, Mohamed
AU - Guan, Jianjun
N1 - Publisher Copyright:
© 2022 American Chemical Society.
PY - 2022/11/22
Y1 - 2022/11/22
N2 - Myocardial infarction (MI) causes massive cell death due to restricted blood flow and oxygen deficiency. Rapid and sustained oxygen delivery following MI rescues cardiac cells and restores cardiac function. However, current oxygen-generating materials cannot be administered during acute MI stage without direct injection or suturing methods, both of which risk rupturing weakened heart tissue. Here, we present infarcted heart-targeting, oxygen-releasing nanoparticles capable of being delivered by intravenous injection at acute MI stage, and specifically accumulating in the infarcted heart. The nanoparticles can also be delivered before MI, then gather at the injured area after MI. We demonstrate that the nanoparticles, delivered either pre-MI or post-MI, enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. Our findings demonstrate that oxygen-delivering nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.
AB - Myocardial infarction (MI) causes massive cell death due to restricted blood flow and oxygen deficiency. Rapid and sustained oxygen delivery following MI rescues cardiac cells and restores cardiac function. However, current oxygen-generating materials cannot be administered during acute MI stage without direct injection or suturing methods, both of which risk rupturing weakened heart tissue. Here, we present infarcted heart-targeting, oxygen-releasing nanoparticles capable of being delivered by intravenous injection at acute MI stage, and specifically accumulating in the infarcted heart. The nanoparticles can also be delivered before MI, then gather at the injured area after MI. We demonstrate that the nanoparticles, delivered either pre-MI or post-MI, enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. Our findings demonstrate that oxygen-delivering nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.
KW - acute myocardial infarction
KW - controlled release of oxygen
KW - myocardial repair
KW - nanoparticles
KW - targeted delivery
UR - http://www.scopus.com/inward/record.url?scp=85141997476&partnerID=8YFLogxK
U2 - 10.1021/acsnano.2c10043
DO - 10.1021/acsnano.2c10043
M3 - Article
C2 - 36367231
AN - SCOPUS:85141997476
SN - 1936-0851
VL - 16
SP - 19551
EP - 19566
JO - ACS nano
JF - ACS nano
IS - 11
ER -