Requirements for Th1-dependent immunity against infection with Leishmania major

Esther Von Stebut; Mark C. Udey

doi:10.1016/j.micinf.2004.05.024

Requirements for Th1-dependent immunity against infection with Leishmania major

Esther Von Stebut, Mark C. Udey

Division of Dermatology

Research output: Contribution to journal › Short survey › peer-review

76 Scopus citations

Abstract

Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.

Original language	English
Pages (from-to)	1102-1109
Number of pages	8
Journal	Microbes and Infection
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/j.micinf.2004.05.024
State	Published - Oct 2004

Keywords

Dendritic cells
IL-12
Leishmania
Macrophages
Th1

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10.1016/j.micinf.2004.05.024

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title = "Requirements for Th1-dependent immunity against infection with Leishmania major",

abstract = "Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.",

keywords = "Dendritic cells, IL-12, Leishmania, Macrophages, Th1",

author = "{Von Stebut}, Esther and Udey, {Mark C.}",

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AU - Von Stebut, Esther

AU - Udey, Mark C.

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AB - Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.

KW - Dendritic cells

KW - IL-12

KW - Leishmania

KW - Macrophages

KW - Th1

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DO - 10.1016/j.micinf.2004.05.024

M3 - Short survey

C2 - 15380780

AN - SCOPUS:4544328132

VL - 6

SP - 1102

EP - 1109

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 12

ER -

Requirements for Th1-dependent immunity against infection with Leishmania major

Abstract

Keywords

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