Requirements for Th1-dependent immunity against infection with Leishmania major

Esther Von Stebut, Mark C. Udey

Research output: Contribution to journalShort surveypeer-review

76 Scopus citations

Abstract

Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.

Original languageEnglish
Pages (from-to)1102-1109
Number of pages8
JournalMicrobes and Infection
Volume6
Issue number12
DOIs
StatePublished - Oct 2004

Keywords

  • Dendritic cells
  • IL-12
  • Leishmania
  • Macrophages
  • Th1

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