Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices

Yukitoshi Izumi, Ken ichi Ito, Hiroyoshi Miyakawa, Hiroshi Kato

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Abstract

Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca2+ with one containing 1.0 mM Ca2+ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca2+ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca2+ after as well as during tetanus.

Original languageEnglish
Pages (from-to)176-180
Number of pages5
JournalNeuroscience Letters
Volume77
Issue number2
DOIs
StatePublished - Jun 15 1987
Externally publishedYes

Keywords

  • Guinea pig
  • Hippocampus
  • Long-term potentiation
  • Loperamide
  • Sliced preparation
  • Verapamil
  • [Ca]

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