Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices

Yukitoshi Izumi; Ken ichi Ito; Hiroyoshi Miyakawa; Hiroshi Kato

doi:10.1016/0304-3940(87)90582-9

Requirement of extracellular Ca²⁺ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices

Yukitoshi Izumi, Ken ichi Ito, Hiroyoshi Miyakawa, Hiroshi Kato

Division of Basic Science Research

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca²⁺ with one containing 1.0 mM Ca²⁺ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca²⁺ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca²⁺ after as well as during tetanus.

Original language	English
Pages (from-to)	176-180
Number of pages	5
Journal	Neuroscience Letters
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(87)90582-9
State	Published - Jun 15 1987

Keywords

Guinea pig
Hippocampus
Long-term potentiation
Loperamide
Sliced preparation
Verapamil
[Ca]

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10.1016/0304-3940(87)90582-9

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title = "Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices",

abstract = "Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca2+ with one containing 1.0 mM Ca2+ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca2+ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca2+ after as well as during tetanus.",

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T1 - Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices

AU - Izumi, Yukitoshi

AU - Ito, Ken ichi

AU - Miyakawa, Hiroyoshi

AU - Kato, Hiroshi

PY - 1987/6/15

Y1 - 1987/6/15

N2 - Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca2+ with one containing 1.0 mM Ca2+ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca2+ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca2+ after as well as during tetanus.

AB - Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca2+ with one containing 1.0 mM Ca2+ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca2+ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca2+ after as well as during tetanus.

KW - Guinea pig

KW - Hippocampus

KW - Long-term potentiation

KW - Loperamide

KW - Sliced preparation

KW - Verapamil

KW - [Ca]

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JO - Neuroscience Letters

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ER -

Requirement of extracellular Ca²⁺ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices

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