TY - JOUR
T1 - Reprogramming the conduction system
T2 - Onward toward a biological pacemaker
AU - Meyers, Jason D.
AU - Jay, Patrick Y.
AU - Rentschler, Stacey
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Diseases of the cardiac conduction system can be debilitating and deadly. Electronic pacemakers are incredibly effective in the treatment of sinus and AV node dysfunction, yet there remain important limitations and complications. These issues have driven interest in the development of a biological pacemaker. Here, we review experimental progress in animal models and discuss future directions, with a focus on reprogramming endogenous cells in the heart to treat defects of rhythm and conduction.
AB - Diseases of the cardiac conduction system can be debilitating and deadly. Electronic pacemakers are incredibly effective in the treatment of sinus and AV node dysfunction, yet there remain important limitations and complications. These issues have driven interest in the development of a biological pacemaker. Here, we review experimental progress in animal models and discuss future directions, with a focus on reprogramming endogenous cells in the heart to treat defects of rhythm and conduction.
UR - http://www.scopus.com/inward/record.url?scp=84958743949&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2015.03.015
DO - 10.1016/j.tcm.2015.03.015
M3 - Review article
C2 - 25937044
AN - SCOPUS:84958743949
SN - 1050-1738
VL - 26
SP - 14
EP - 20
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 1
ER -