TY - JOUR
T1 - Reprogramming antitumor immunity
AU - Crompton, Joseph G.
AU - Clever, David
AU - Vizcardo, Raul
AU - Rao, Mahendra
AU - Restifo, Nicholas P.
PY - 2014/4
Y1 - 2014/4
N2 - Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context, envision how the scope of regenerative medicine may be expanded to treat metastatic cancer by revitalizing an exhausted and senescent immune system.
AB - Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context, envision how the scope of regenerative medicine may be expanded to treat metastatic cancer by revitalizing an exhausted and senescent immune system.
KW - Cancer immunotherapy
KW - Regenerative medicine
KW - T cell reprogramming
UR - http://www.scopus.com/inward/record.url?scp=84897448841&partnerID=8YFLogxK
U2 - 10.1016/j.it.2014.02.003
DO - 10.1016/j.it.2014.02.003
M3 - Review article
C2 - 24661777
AN - SCOPUS:84897448841
SN - 1471-4906
VL - 35
SP - 178
EP - 185
JO - Trends in Immunology
JF - Trends in Immunology
IS - 4
ER -