TY - JOUR
T1 - Reproductive late effects after hematopoietic stem cell transplant in pediatric, adolescent, and young adult cancer survivors
AU - Appiah, Leslie C.
AU - Moravek, Molly
AU - Hoefgen, Holly
AU - Rotz, Seth
AU - Childress, Krista
AU - Samis, Jill
AU - Benoit, Janie
AU - Rodriguez-Wallberg, Kenny
AU - Anazodo, Antoinette
N1 - Publisher Copyright:
© 2023 Wiley Periodicals LLC.
PY - 2023/9
Y1 - 2023/9
N2 - Reproductive late effects after hematopoietic stem cell transplant can have a significant impact on cancer survivors’ quality of life. Potential late effects include gonadal insufficiency, genital graft-versus-host disease, uterine injury, psychosexual dysfunction, and an increased risk of breast and cervical cancer in patients treated with total body irradiation. Despite guidelines, screening and treatment are not standardized among at-risk patients. Provider barriers include lack of knowledge of at-risk therapies and evidenced-based guidelines. Patient barriers include a reluctance to report symptoms and lack of awareness of treatment options. System barriers include inefficient implementation of screening tools and poor dissemination of guidelines to providers who serve as the medical home for survivors. This review guides the clinician in identifying and managing reproductive late effects after hematopoietic stem cell transplant to improve outcomes.
AB - Reproductive late effects after hematopoietic stem cell transplant can have a significant impact on cancer survivors’ quality of life. Potential late effects include gonadal insufficiency, genital graft-versus-host disease, uterine injury, psychosexual dysfunction, and an increased risk of breast and cervical cancer in patients treated with total body irradiation. Despite guidelines, screening and treatment are not standardized among at-risk patients. Provider barriers include lack of knowledge of at-risk therapies and evidenced-based guidelines. Patient barriers include a reluctance to report symptoms and lack of awareness of treatment options. System barriers include inefficient implementation of screening tools and poor dissemination of guidelines to providers who serve as the medical home for survivors. This review guides the clinician in identifying and managing reproductive late effects after hematopoietic stem cell transplant to improve outcomes.
KW - adolescent
KW - genital graft-versus-host disease
KW - gonadal insufficiency
KW - hematopoietic stem cell transplant
KW - hormone therapy
KW - pediatric
KW - radiation-induced breast cancer
KW - radiation-induced uterine injury
KW - reproductive late effects
KW - young adult (AYA) cancer
UR - http://www.scopus.com/inward/record.url?scp=85165459471&partnerID=8YFLogxK
U2 - 10.1002/pbc.30551
DO - 10.1002/pbc.30551
M3 - Review article
C2 - 37470746
AN - SCOPUS:85165459471
SN - 1545-5009
VL - 70
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - S5
M1 - e30551
ER -