TY - JOUR
T1 - Reproductive factors, smoking, and the risk for rheumatoid arthritis
AU - Avila, Mauricio Hernández
AU - Liang, Matthew H.
AU - Willett, Walter C.
AU - Stampfer, Meir J.
AU - Colditz, Graham A.
AU - Rosner, Bernard
AU - Roberts, W. Neal
AU - Hennekens, Charles H.
AU - Speizer, Frank E.
PY - 1990/7
Y1 - 1990/7
N2 - Risk factors for rheumatoid arthritis were examined in a cohort of 121,700 female nurses aged 30–55, followed in the Nurses’ Health Study. Baseline information on reproductive variables, cigarette smoking, obesity, and other variables was obtained in 1976 and updated every 2 years. Cases of rheumatoid arthritis were defined by standardized questionnaire and review of medical records. During 883, 187 person-years of follow-up, 217 new cases of rheumatoid arthritis were identified (115 had definite rheumatoid arthritis and 102 had “undifferentiated polyarthritis”). When compared with women who experienced menarche at age 13 years, the age-adjusted relative risk of rheumatoid arthritis among women with early menarche was 1.9 (95% confidence interval, 0.9–2.4). There were, however, no significant associations between parity, age at birth of the first child, menopause, or obesity and the incidence of rheumatoid arthritis. Cigarette smokers had a slight apparent increase in the risk of rheumatoid arthritis. Among current smokers, the age-adjusted relative risk for RA rheumatoid arthritis was 1.3 (0.9–2.1); among former smokers, the relative risk was 1.5 (0.9–2.3). (Epidemiology 1990;l:285–291).
AB - Risk factors for rheumatoid arthritis were examined in a cohort of 121,700 female nurses aged 30–55, followed in the Nurses’ Health Study. Baseline information on reproductive variables, cigarette smoking, obesity, and other variables was obtained in 1976 and updated every 2 years. Cases of rheumatoid arthritis were defined by standardized questionnaire and review of medical records. During 883, 187 person-years of follow-up, 217 new cases of rheumatoid arthritis were identified (115 had definite rheumatoid arthritis and 102 had “undifferentiated polyarthritis”). When compared with women who experienced menarche at age 13 years, the age-adjusted relative risk of rheumatoid arthritis among women with early menarche was 1.9 (95% confidence interval, 0.9–2.4). There were, however, no significant associations between parity, age at birth of the first child, menopause, or obesity and the incidence of rheumatoid arthritis. Cigarette smokers had a slight apparent increase in the risk of rheumatoid arthritis. Among current smokers, the age-adjusted relative risk for RA rheumatoid arthritis was 1.3 (0.9–2.1); among former smokers, the relative risk was 1.5 (0.9–2.3). (Epidemiology 1990;l:285–291).
KW - Questionnaires
KW - Reproductive factors
KW - Rheumatoid arthritis
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=0025042176&partnerID=8YFLogxK
U2 - 10.1097/00001648-199007000-00005
DO - 10.1097/00001648-199007000-00005
M3 - Article
C2 - 2083305
AN - SCOPUS:0025042176
SN - 1044-3983
VL - 1
SP - 285
EP - 291
JO - Epidemiology
JF - Epidemiology
IS - 4
ER -