Reproducibility of resting cerebral blood flow measurements with H215O positron emission tomography in humans

Elizabeth Matthew; Paul Andreason; Richard E. Carson; Peter Herscovitch; Karen Pettigrew; Robert Cohen; Catherine King; Chris Ellyn Johanson; Steven M. Paul

doi:10.1038/jcbfm.1993.95

Reproducibility of resting cerebral blood flow measurements with H₂¹⁵O positron emission tomography in humans

Elizabeth Matthew, Paul Andreason, Richard E. Carson, Peter Herscovitch, Karen Pettigrew, Robert Cohen, Catherine King, Chris Ellyn Johanson, Steven M. Paul

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H₂¹⁵O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g^-1 min^-1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

Original language	English
Pages (from-to)	748-754
Number of pages	7
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	13
Issue number	5
DOIs	https://doi.org/10.1038/jcbfm.1993.95
State	Published - 1993

Keywords

Ho positron emission tomography
Normalization of data
Regions of interest
Reproducibility of measurement
Resting cerebral blood flow

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10.1038/jcbfm.1993.95

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title = "Reproducibility of resting cerebral blood flow measurements with H215O positron emission tomography in humans",

abstract = "Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H215O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.",

keywords = "Ho positron emission tomography, Normalization of data, Regions of interest, Reproducibility of measurement, Resting cerebral blood flow",

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T1 - Reproducibility of resting cerebral blood flow measurements with H215O positron emission tomography in humans

AU - Matthew, Elizabeth

AU - Andreason, Paul

AU - Carson, Richard E.

AU - Herscovitch, Peter

AU - Pettigrew, Karen

AU - Cohen, Robert

AU - King, Catherine

AU - Johanson, Chris Ellyn

AU - Paul, Steven M.

PY - 1993

Y1 - 1993

N2 - Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H215O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

AB - Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H215O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

KW - Ho positron emission tomography

KW - Normalization of data

KW - Regions of interest

KW - Reproducibility of measurement

KW - Resting cerebral blood flow

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Reproducibility of resting cerebral blood flow measurements with H₂¹⁵O positron emission tomography in humans

Abstract

Keywords

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