Reproducibility of resting cerebral blood flow measurements with H215O positron emission tomography in humans

Elizabeth Matthew, Paul Andreason, Richard E. Carson, Peter Herscovitch, Karen Pettigrew, Robert Cohen, Catherine King, Chris Ellyn Johanson, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H215O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

Original languageEnglish
Pages (from-to)748-754
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1993

Keywords

  • Ho positron emission tomography
  • Normalization of data
  • Regions of interest
  • Reproducibility of measurement
  • Resting cerebral blood flow

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