Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia

Robert I. Liem; Jingxia Liu; Mae O. Gordon; Bruce A. Vendt; Robert C. McKinstry; Michael A. Kraut; John J. Strouse; William S. Ball; Michael R. DeBaun

doi:10.1177/0883073813506491

Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia

Robert I. Liem, Jingxia Liu, Mae O. Gordon, Bruce A. Vendt, Robert C. McKinstry, Michael A. Kraut, John J. Strouse, William S. Ball, Michael R. DeBaun

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Detecting silent cerebral infarcts on magnetic resonance images (MRIs) in children with sickle cell anemia is challenging, yet reproducibility of readings has not been examined in this population. We evaluated consensus rating, inter-, and intra-grader agreement associated with detecting silent cerebral infarct on screening MRI in the Silent Infarct Transfusion Trial. Three neuroradiologists provided consensus decisions for 1073 MRIs. A random sample of 53 scans was reanalyzed in blinded fashion. Agreement between first and second consensus ratings was substantial (κ = 0.70, P < .0001), as was overall intergrader agreement (κ = 0.76, P < .0001). In the test-retest sample, intragrader agreement ranged from k of 0.57 to 0.76. Consensus decisions were more concordant when MRIs contained more than one larger lesions. Routine use of MRI to screen for silent cerebral infarcts in the research setting is reproducible in sickle cell anemia and agreement among neuroradiologists is sufficient.

Original language	English
Pages (from-to)	1685-1691
Number of pages	7
Journal	Journal of Child Neurology
Volume	29
Issue number	12
DOIs	https://doi.org/10.1177/0883073813506491
State	Published - Dec 2014

Keywords

Reliability testing
Sickle cell disease
Stroke

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title = "Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia",

abstract = "Detecting silent cerebral infarcts on magnetic resonance images (MRIs) in children with sickle cell anemia is challenging, yet reproducibility of readings has not been examined in this population. We evaluated consensus rating, inter-, and intra-grader agreement associated with detecting silent cerebral infarct on screening MRI in the Silent Infarct Transfusion Trial. Three neuroradiologists provided consensus decisions for 1073 MRIs. A random sample of 53 scans was reanalyzed in blinded fashion. Agreement between first and second consensus ratings was substantial (κ = 0.70, P < .0001), as was overall intergrader agreement (κ = 0.76, P < .0001). In the test-retest sample, intragrader agreement ranged from k of 0.57 to 0.76. Consensus decisions were more concordant when MRIs contained more than one larger lesions. Routine use of MRI to screen for silent cerebral infarcts in the research setting is reproducible in sickle cell anemia and agreement among neuroradiologists is sufficient.",

keywords = "Reliability testing, Sickle cell disease, Stroke",

author = "Liem, {Robert I.} and Jingxia Liu and Gordon, {Mae O.} and Vendt, {Bruce A.} and McKinstry, {Robert C.} and Kraut, {Michael A.} and Strouse, {John J.} and Ball, {William S.} and DeBaun, {Michael R.}",

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year = "2014",

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doi = "10.1177/0883073813506491",

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AU - Liem, Robert I.

AU - Liu, Jingxia

AU - Gordon, Mae O.

AU - Vendt, Bruce A.

AU - McKinstry, Robert C.

AU - Kraut, Michael A.

AU - Strouse, John J.

AU - Ball, William S.

AU - DeBaun, Michael R.

N1 - Publisher Copyright: © The Author(s) 2013.

PY - 2014/12

Y1 - 2014/12

N2 - Detecting silent cerebral infarcts on magnetic resonance images (MRIs) in children with sickle cell anemia is challenging, yet reproducibility of readings has not been examined in this population. We evaluated consensus rating, inter-, and intra-grader agreement associated with detecting silent cerebral infarct on screening MRI in the Silent Infarct Transfusion Trial. Three neuroradiologists provided consensus decisions for 1073 MRIs. A random sample of 53 scans was reanalyzed in blinded fashion. Agreement between first and second consensus ratings was substantial (κ = 0.70, P < .0001), as was overall intergrader agreement (κ = 0.76, P < .0001). In the test-retest sample, intragrader agreement ranged from k of 0.57 to 0.76. Consensus decisions were more concordant when MRIs contained more than one larger lesions. Routine use of MRI to screen for silent cerebral infarcts in the research setting is reproducible in sickle cell anemia and agreement among neuroradiologists is sufficient.

AB - Detecting silent cerebral infarcts on magnetic resonance images (MRIs) in children with sickle cell anemia is challenging, yet reproducibility of readings has not been examined in this population. We evaluated consensus rating, inter-, and intra-grader agreement associated with detecting silent cerebral infarct on screening MRI in the Silent Infarct Transfusion Trial. Three neuroradiologists provided consensus decisions for 1073 MRIs. A random sample of 53 scans was reanalyzed in blinded fashion. Agreement between first and second consensus ratings was substantial (κ = 0.70, P < .0001), as was overall intergrader agreement (κ = 0.76, P < .0001). In the test-retest sample, intragrader agreement ranged from k of 0.57 to 0.76. Consensus decisions were more concordant when MRIs contained more than one larger lesions. Routine use of MRI to screen for silent cerebral infarcts in the research setting is reproducible in sickle cell anemia and agreement among neuroradiologists is sufficient.

KW - Reliability testing

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JO - Journal of Child Neurology

JF - Journal of Child Neurology

IS - 12

ER -

Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia

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