Reproducibility of blood pressure responses to dietary sodium and potassium interventions: The GenSalt study

Dongfeng Gu, Qi Zhao, Jing Chen, Ji Chun Chen, Jianfeng Huang, Lydia A. Bazzano, Fanghong Lu, Jianjun Mu, Jianxin Li, Jie Cao, Katherine Mills, Chung Shiuan Chen, Treva Rice, L. Lee Hamm, Jiang He

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Blood pressure responses to dietary sodium and potassium interventions vary among individuals. We studied the long-term reproducibility of blood pressure responses to dietary sodium and potassium intake. We repeated the dietary sodium and potassium interventions among 487 Chinese adults 4.5 years after the original dietary intervention. The identical dietary intervention protocol, which included a 7-day low-sodium feeding (51.3 mmol/d), a 7-day high-sodium feeding (307.8 mmol/d), and a 7-day high-sodium feeding with oral potassium supplementation (60.0 mmol/d), was applied in both the initial and repeated studies. Three blood pressure measurements were obtained during each of the 3 days of baseline observation and on days 5, 6, and 7 of each intervention period. The results from the 24-hour urinary excretion of sodium and potassium showed excellent compliance with the study diet. Blood pressure responses to dietary intervention in the original and repeated studies were highly correlated. For example, the correlation coefficients (95% confidence interval) for systolic blood pressure levels were 0.77 (0.73-0.80) at baseline, 0.79 (0.75-0.82) during low sodium, 0.80 (0.77-0.83) during high sodium, and 0.82 (0.79-0.85) during high sodium and potassium supplementation interventions (all P<0.0001). The correlation coefficients for systolic blood pressure changes were 0.37 (0.29-0.44) from baseline to low sodium, 0.37 (0.29-0.44) from low to high sodium, and 0.28 (0.20-0.36) from high sodium to high sodium plus potassium supplementation (all P<0.0001). These data indicate that blood pressure responses to dietary sodium and potassium interventions have long-term reproducibility and stable characteristics in the general population.

Original languageEnglish
Pages (from-to)499-505
Number of pages7
JournalHypertension
Volume62
Issue number3
DOIs
StatePublished - Sep 1 2013

Keywords

  • blood pressure
  • potassium, dietary
  • reproducibility of results
  • sodium, dietary

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    Gu, D., Zhao, Q., Chen, J., Chen, J. C., Huang, J., Bazzano, L. A., Lu, F., Mu, J., Li, J., Cao, J., Mills, K., Chen, C. S., Rice, T., Hamm, L. L., & He, J. (2013). Reproducibility of blood pressure responses to dietary sodium and potassium interventions: The GenSalt study. Hypertension, 62(3), 499-505. https://doi.org/10.1161/HYPERTENSIONAHA.113.01034