Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency

Stephen F. Kry; Jessica Lye; Catharine H. Clark; Nicolaus Andratschke; Alexis Dimitriadis; David Followill; Rebecca Howell; Mohammad Hussein; Masayori Ishikawa; Satoshi Kito; Tomas Kron; Jonny Lee; Jeff Michalski; Angelo Filippo Monti; Nick Reynaert; Paige Taylor; Karen Venables; Ying Xiao; Joerg Lehmann

doi:10.1016/j.radonc.2021.03.006

Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency

Stephen F. Kry, Jessica Lye, Catharine H. Clark, Nicolaus Andratschke, Alexis Dimitriadis, David Followill, Rebecca Howell, Mohammad Hussein, Masayori Ishikawa, Satoshi Kito, Tomas Kron, Jonny Lee, Jeff Michalski, Angelo Filippo Monti, Nick Reynaert, Paige Taylor, Karen Venables, Ying Xiao, Joerg Lehmann

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Purpose: To promote consistency in clinical trials by recommending a uniform framework as it relates to radiation transport and dose calculation in water versus in medium. Methods: The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonisation Group (GHG; www.rtqaharmonization.org) compared the differences between dose to water in water (D_w,w), dose to water in medium (D_w,m), and dose to medium in medium (D_m,m). This was done based on a review of historical frameworks, existing literature and standards, clinical issues in the context of clinical trials, and the trajectory of radiation dose calculations. Based on these factors, recommendations were developed. Results: No framework was found to be ideal or perfect given the history, complexity, and current status of radiation therapy. Nevertheless, based on the evidence available, the GHG established a recommendation preferring dose to medium in medium (D_m,m). Conclusions: Dose to medium in medium (D_m,m) is the preferred dose calculation and reporting framework. If an institution's planning system can only calculate dose to water in water (D_w,w), this is acceptable.

Original language	English
Pages (from-to)	106-111
Number of pages	6
Journal	Radiotherapy and Oncology
Volume	159
DOIs	https://doi.org/10.1016/j.radonc.2021.03.006
State	Published - Jun 2021

Keywords

Clinical trial
Dose calculation
Dose to medium, Dose to water
GHG
Radiation dosage

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10.1016/j.radonc.2021.03.006

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Kry, S. F., Lye, J., Clark, C. H., Andratschke, N., Dimitriadis, A., Followill, D., Howell, R., Hussein, M., Ishikawa, M., Kito, S., Kron, T., Lee, J., Michalski, J., Filippo Monti, A., Reynaert, N., Taylor, P., Venables, K., Xiao, Y., & Lehmann, J. (2021). Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency. Radiotherapy and Oncology, 159, 106-111. https://doi.org/10.1016/j.radonc.2021.03.006

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title = "Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency",

abstract = "Purpose: To promote consistency in clinical trials by recommending a uniform framework as it relates to radiation transport and dose calculation in water versus in medium. Methods: The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonisation Group (GHG; www.rtqaharmonization.org) compared the differences between dose to water in water (Dw,w), dose to water in medium (Dw,m), and dose to medium in medium (Dm,m). This was done based on a review of historical frameworks, existing literature and standards, clinical issues in the context of clinical trials, and the trajectory of radiation dose calculations. Based on these factors, recommendations were developed. Results: No framework was found to be ideal or perfect given the history, complexity, and current status of radiation therapy. Nevertheless, based on the evidence available, the GHG established a recommendation preferring dose to medium in medium (Dm,m). Conclusions: Dose to medium in medium (Dm,m) is the preferred dose calculation and reporting framework. If an institution's planning system can only calculate dose to water in water (Dw,w), this is acceptable.",

keywords = "Clinical trial, Dose calculation, Dose to medium, Dose to water, GHG, Radiation dosage",

author = "Kry, {Stephen F.} and Jessica Lye and Clark, {Catharine H.} and Nicolaus Andratschke and Alexis Dimitriadis and David Followill and Rebecca Howell and Mohammad Hussein and Masayori Ishikawa and Satoshi Kito and Tomas Kron and Jonny Lee and Jeff Michalski and {Filippo Monti}, Angelo and Nick Reynaert and Paige Taylor and Karen Venables and Ying Xiao and Joerg Lehmann",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = jun,

doi = "10.1016/j.radonc.2021.03.006",

language = "English",

volume = "159",

pages = "106--111",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

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Kry, SF, Lye, J, Clark, CH, Andratschke, N, Dimitriadis, A, Followill, D, Howell, R, Hussein, M, Ishikawa, M, Kito, S, Kron, T, Lee, J, Michalski, J, Filippo Monti, A, Reynaert, N, Taylor, P, Venables, K, Xiao, Y & Lehmann, J 2021, 'Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency', Radiotherapy and Oncology, vol. 159, pp. 106-111. https://doi.org/10.1016/j.radonc.2021.03.006

TY - JOUR

T1 - Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency

AU - Kry, Stephen F.

AU - Lye, Jessica

AU - Clark, Catharine H.

AU - Andratschke, Nicolaus

AU - Dimitriadis, Alexis

AU - Followill, David

AU - Howell, Rebecca

AU - Hussein, Mohammad

AU - Ishikawa, Masayori

AU - Kito, Satoshi

AU - Kron, Tomas

AU - Lee, Jonny

AU - Michalski, Jeff

AU - Filippo Monti, Angelo

AU - Reynaert, Nick

AU - Taylor, Paige

AU - Venables, Karen

AU - Xiao, Ying

AU - Lehmann, Joerg

PY - 2021/6

Y1 - 2021/6

N2 - Purpose: To promote consistency in clinical trials by recommending a uniform framework as it relates to radiation transport and dose calculation in water versus in medium. Methods: The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonisation Group (GHG; www.rtqaharmonization.org) compared the differences between dose to water in water (Dw,w), dose to water in medium (Dw,m), and dose to medium in medium (Dm,m). This was done based on a review of historical frameworks, existing literature and standards, clinical issues in the context of clinical trials, and the trajectory of radiation dose calculations. Based on these factors, recommendations were developed. Results: No framework was found to be ideal or perfect given the history, complexity, and current status of radiation therapy. Nevertheless, based on the evidence available, the GHG established a recommendation preferring dose to medium in medium (Dm,m). Conclusions: Dose to medium in medium (Dm,m) is the preferred dose calculation and reporting framework. If an institution's planning system can only calculate dose to water in water (Dw,w), this is acceptable.

AB - Purpose: To promote consistency in clinical trials by recommending a uniform framework as it relates to radiation transport and dose calculation in water versus in medium. Methods: The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonisation Group (GHG; www.rtqaharmonization.org) compared the differences between dose to water in water (Dw,w), dose to water in medium (Dw,m), and dose to medium in medium (Dm,m). This was done based on a review of historical frameworks, existing literature and standards, clinical issues in the context of clinical trials, and the trajectory of radiation dose calculations. Based on these factors, recommendations were developed. Results: No framework was found to be ideal or perfect given the history, complexity, and current status of radiation therapy. Nevertheless, based on the evidence available, the GHG established a recommendation preferring dose to medium in medium (Dm,m). Conclusions: Dose to medium in medium (Dm,m) is the preferred dose calculation and reporting framework. If an institution's planning system can only calculate dose to water in water (Dw,w), this is acceptable.

KW - Clinical trial

KW - Dose calculation

KW - Dose to medium, Dose to water

KW - GHG

KW - Radiation dosage

UR - http://www.scopus.com/inward/record.url?scp=85103613161&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2021.03.006

DO - 10.1016/j.radonc.2021.03.006

M3 - Review article

C2 - 33741471

AN - SCOPUS:85103613161

SN - 0167-8140

VL - 159

SP - 106

EP - 111

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency

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Keywords

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