Replication stress: Getting back on track

Matteo Berti; Alessandro Vindigni

doi:10.1038/nsmb.3163

Replication stress: Getting back on track

Matteo Berti, Alessandro Vindigni

Research output: Contribution to journal › Review article › peer-review

190 Scopus citations

Abstract

The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Nature Structural and Molecular Biology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1038/nsmb.3163
State	Published - Feb 3 2016

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Replication stress: Getting back on track

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