TY - JOUR
T1 - Replication stress
T2 - Getting back on track
AU - Berti, Matteo
AU - Vindigni, Alessandro
N1 - Funding Information:
We thank Y. Ayala, A. Costa, J. Eissenberg, M. Lopes, P. Pasero and M. Seidman for their careful reading of the manuscript and insightful comments. Work in the laboratory of A.V. is supported by US National Institutes of Health grant R01GM108648.
Publisher Copyright:
© 2016 Nature America, Inc.
PY - 2016/2/3
Y1 - 2016/2/3
N2 - The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.
AB - The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.
UR - http://www.scopus.com/inward/record.url?scp=84956887909&partnerID=8YFLogxK
U2 - 10.1038/nsmb.3163
DO - 10.1038/nsmb.3163
M3 - Review article
C2 - 26840898
AN - SCOPUS:84956887909
VL - 23
SP - 103
EP - 109
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
SN - 1545-9993
IS - 2
ER -