TY - JOUR
T1 - Replication slippage may cause parallel evolution in the secondary structures of mitochondrial transfer RNAs
AU - Macey, J. Robert
AU - Larson, Allan
AU - Ananjeva, Natalia B.
AU - Papenfuss, Theodore J.
PY - 1997/1
Y1 - 1997/1
N2 - Presence of the dihydrouridine (D) stem in the mitochondrial cysteine tRNA is unusually variable among lepidosaurian reptiles. Phylogenetic and comparative analyses of cysteine tRNA gene sequences identify eight parallel losses of the D-stem, resulting in D-arm replacement loops. Sampling within the monophyletic Acrodonta provides no evidence for reversal. Slipped-strand mispairing of noncontiguous repeated sequences during replication or direct replication slippage can explain repeats observed within cysteine tRNAs that contain a D-arm replacement loop. These two mechanisms involving replication slippage can account for the loss of the cysteine tRNA D-stem in several lepidosaurian lineages, and may represent general mechanisms by which the secondary structures of mitochondrial tRNAs are altered.
AB - Presence of the dihydrouridine (D) stem in the mitochondrial cysteine tRNA is unusually variable among lepidosaurian reptiles. Phylogenetic and comparative analyses of cysteine tRNA gene sequences identify eight parallel losses of the D-stem, resulting in D-arm replacement loops. Sampling within the monophyletic Acrodonta provides no evidence for reversal. Slipped-strand mispairing of noncontiguous repeated sequences during replication or direct replication slippage can explain repeats observed within cysteine tRNAs that contain a D-arm replacement loop. These two mechanisms involving replication slippage can account for the loss of the cysteine tRNA D-stem in several lepidosaurian lineages, and may represent general mechanisms by which the secondary structures of mitochondrial tRNAs are altered.
KW - cysteine transfer RNA
KW - mitochondrial DNA
KW - phylogenetic
KW - reptile
UR - http://www.scopus.com/inward/record.url?scp=0031031728&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.molbev.a025699
DO - 10.1093/oxfordjournals.molbev.a025699
M3 - Article
AN - SCOPUS:0031031728
SN - 0737-4038
VL - 14
SP - 30
EP - 39
JO - Molecular biology and evolution
JF - Molecular biology and evolution
IS - 1
ER -