Replication of attention-deficit/hyperactivity (ADHD) latent class structure in a sample of Australian twins

E. R. Rasmussen, R. J. Neuman, A. C. Heath, M. McStephen, D. A. Hay, R. D. Todd

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Previous research using latent class analysis to detect ADHD subtypes based on DSM-IV symptom profiles has identified distinct, heritable phenotypes within the domains of inattention, hyperactivity-impulsivity and combined-type problems. The goal of the current research is to attempt to replicate the latent class structure in a different sample. Nine latent class models were fitted to the symptom profiles N=1432 female and N=1416 male Australian twins separately by sex. As in the Missouri sample, an 8-class solution was the best fitting model. Congruent with previous findings, substantial overlap between the DSM-IV combined subtype and severe- combined latent class membership was detected, however 60% of females and 44% of males wit no diagnosis were assigned to this class. Among DSM-IV inattentive subtypes, 84% of females and 96% of males were assigned to either the moderate or severe-inattentive classes, and the remaining cases were assigned to the moderate or severe-combined classes. 70% of individuals across all inattentive classes did not meet DSM-IV ADHD criteria. In conclusion, the latent class phenotypes only partially overlap, suggesting that the DSM nomenclature may have limited utility serving as phenotypes in genetic studies of ADHD.

Original languageEnglish
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number4
StatePublished - Aug 7 2000


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