Replication Fork Reversal: Players and Guardians

Annabel Quinet, Delphine Lemaçon, Alessandro Vindigni

Research output: Contribution to journalReview articlepeer-review

172 Scopus citations


Replication fork reversal is a rapidly emerging and remarkably frequent mechanism of fork stabilization in response to genotoxic insults. Here, we summarize recent findings that uncover key molecular determinants for reversed fork formation and describe how the homologous recombination factors BRCA1, BRCA2, and RAD51 protect these structures from extended nucleolytic degradation. Replication fork reversal is a central mechanism of fork stabilization. Quinet et al. review recent findings on the mechanisms of reversed fork formation and on the role of key homologous recombination factors in protecting reversed forks from nucleolytic degradation.

Original languageEnglish
Pages (from-to)830-833
Number of pages4
JournalMolecular cell
Issue number5
StatePublished - Dec 7 2017


  • BRCA1
  • BRCA2
  • DNA repair
  • DNA replication
  • fork regression
  • genome instability
  • homologous recombination
  • replication fork restart
  • replication fork reversal
  • replication stress


Dive into the research topics of 'Replication Fork Reversal: Players and Guardians'. Together they form a unique fingerprint.

Cite this