Replication Fork Reversal: Players and Guardians

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127 Scopus citations

Abstract

Replication fork reversal is a rapidly emerging and remarkably frequent mechanism of fork stabilization in response to genotoxic insults. Here, we summarize recent findings that uncover key molecular determinants for reversed fork formation and describe how the homologous recombination factors BRCA1, BRCA2, and RAD51 protect these structures from extended nucleolytic degradation. Replication fork reversal is a central mechanism of fork stabilization. Quinet et al. review recent findings on the mechanisms of reversed fork formation and on the role of key homologous recombination factors in protecting reversed forks from nucleolytic degradation.

Original languageEnglish
Pages (from-to)830-833
Number of pages4
JournalMolecular cell
Volume68
Issue number5
DOIs
StatePublished - Dec 7 2017

Keywords

  • BRCA1
  • BRCA2
  • DNA repair
  • DNA replication
  • fork regression
  • genome instability
  • homologous recombination
  • replication fork restart
  • replication fork reversal
  • replication stress

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