TY - JOUR
T1 - Replication and reliability of Parkinson's disease clinical subtypes
AU - Cash, Therese V.
AU - Lessov-Schlaggar, Christina N.
AU - Foster, Erin R.
AU - Myers, Peter S.
AU - Jackson, Joshua J.
AU - Maiti, Baijayanta
AU - Kotzbauer, Paul T.
AU - Perlmutter, Joel S.
AU - Campbell, Meghan C.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/7
Y1 - 2024/7
N2 - Background: We recently identified three distinct Parkinson's disease subtypes: “motor only” (predominant motor deficits with intact cognition and psychiatric function); “psychiatric & motor” (prominent psychiatric symptoms and moderate motor deficits); “cognitive & motor” (cognitive and motor deficits). Objective: We used an independent cohort to replicate and assess reliability of these Parkinson's disease subtypes. Methods: We tested our original subtype classification with an independent cohort (N = 100) of Parkinson's disease participants without dementia and the same comprehensive evaluations assessing motor, cognitive, and psychiatric function. Next, we combined the original (N = 162) and replication (N = 100) datasets to test the classification model with the full combined dataset (N = 262). We also generated 10 random split-half samples of the combined dataset to establish the reliability of the subtype classifications. Latent class analyses were applied to the replication, combined, and split-half samples to determine subtype classification. Results: First, LCA supported the three-class solution – Motor Only, Psychiatric & Motor, and Cognitive & Motor– in the replication sample. Next, using the larger, combined sample, LCA again supported the three subtype groups, with the emergence of a potential fourth group defined by more severe motor deficits. Finally, split-half analyses showed that the three-class model also had the best fit in 13/20 (65%) split-half samples; two-class and four-class solutions provided the best model fit in five (25%) and two (10%) split-half replications, respectively. Conclusions: These results support the reproducibility and reliability of the Parkinson's disease behavioral subtypes of motor only, psychiatric & motor, and cognitive & motor groups.
AB - Background: We recently identified three distinct Parkinson's disease subtypes: “motor only” (predominant motor deficits with intact cognition and psychiatric function); “psychiatric & motor” (prominent psychiatric symptoms and moderate motor deficits); “cognitive & motor” (cognitive and motor deficits). Objective: We used an independent cohort to replicate and assess reliability of these Parkinson's disease subtypes. Methods: We tested our original subtype classification with an independent cohort (N = 100) of Parkinson's disease participants without dementia and the same comprehensive evaluations assessing motor, cognitive, and psychiatric function. Next, we combined the original (N = 162) and replication (N = 100) datasets to test the classification model with the full combined dataset (N = 262). We also generated 10 random split-half samples of the combined dataset to establish the reliability of the subtype classifications. Latent class analyses were applied to the replication, combined, and split-half samples to determine subtype classification. Results: First, LCA supported the three-class solution – Motor Only, Psychiatric & Motor, and Cognitive & Motor– in the replication sample. Next, using the larger, combined sample, LCA again supported the three subtype groups, with the emergence of a potential fourth group defined by more severe motor deficits. Finally, split-half analyses showed that the three-class model also had the best fit in 13/20 (65%) split-half samples; two-class and four-class solutions provided the best model fit in five (25%) and two (10%) split-half replications, respectively. Conclusions: These results support the reproducibility and reliability of the Parkinson's disease behavioral subtypes of motor only, psychiatric & motor, and cognitive & motor groups.
KW - Classification
KW - Latent class analysis
KW - Parkinson disease
KW - Psychometrics
UR - http://www.scopus.com/inward/record.url?scp=85194816377&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2024.107016
DO - 10.1016/j.parkreldis.2024.107016
M3 - Article
C2 - 38838453
AN - SCOPUS:85194816377
SN - 1353-8020
VL - 124
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
M1 - 107016
ER -