The Collaborative Study on the Genetics of Alcoholism (COGA) is a six-center program to detect and map genes that increase or decrease susceptibility to develop alcohol dependence and related phenotypes. A genome wide screen examined 291 markers in 987 individuals from 105 families at an average interval of 13.8 cM. Multipoint nonparametric linkage analysis provided suggestive evidence for linkage with susceptibility loci for broadly defined alcohol dependence on chromosomes 1, 2, and 7. Using a narrowly defined severe alcohol dependence phenotype, suggestive evidence for linkage on chromosomes 8 and 16 was found. There was also suggestive evidence for linkage with a protective locus on chromosome 4, for which protective effects have been reported in Asian populations. Replication of these results is being undertaken by (1) dense mapping of hot spots identified in the initial screen and by (2) mapping regions of interest in a large replication sample. The replication sample, currently being genotyped, includes 157 families with 1,319 members. Preliminary results from dense mapping studies of the initial sample suggest continued evidence for linkage on chromosomes 4 and 16. These findings and more detailed results of dense mapping on the initial sample and preliminary linkage results from the replication sample will be presented.
|Number of pages||2|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|State||Published - Nov 6 1998|