TY - JOUR
T1 - Replicated psychometric correlates of schizophrenia
AU - Moldin, S. O.
AU - Gottesman, I. I.
AU - Rice, J. P.
AU - Erlenmeyer-Kimling, L.
PY - 1991/6
Y1 - 1991/6
N2 - Objective: The authors' goals are to use scales from the MMPI hypothesized in their previous research to be correlates of liability to schizophrenia to differentiate DSM-III schizophrenia from bipolar and unipolar affective illness and to cross-validate these correlates in an independently ascertained sample of patients with Research Diagnostic Criteria (RDC) schizophrenia or affective disorder. Method: The criterion sample consisted of 83 patients consecutively admitted to a state-operated community mental health center. Diagnoses of schizophrenia; bipolar disorder, manic; and major depression were assigned by using DSM-III. The replication sample consisted of 60 adults with RDC diagnoses of schizophrenia, schizoaffective disorder, bipolar disorder, and unipolar disorder who were parents of children in two samples collected for a study of offspring at high risk for schizophrenia and other psychopathology. After the patients in the criterion sample were classified by logistic regres-sion analysis, the results were used to classify patients in the replication sample. Results: The MMPI indicators had adequate sensitivity, specificity, and predictive power for classifying schizophrenia, and there was a moderately high rate of diagnostic agreement between the MMPI and DSM-III. Cross-validation in the replication sample was successful. Overall, the MMPI index was an adequate inclusion and exclusion criterion not only for DSM-lll-defined but also for RDC-defined schizophrenia. Conclusions: A psychometric index composed of the paranoid schizophrenia, psychoticism, and manifest hostility scales from the MMP/ would be a cost-effective measure to increase diagnostic efficiency in future schizophrenia research and clinical practice.
AB - Objective: The authors' goals are to use scales from the MMPI hypothesized in their previous research to be correlates of liability to schizophrenia to differentiate DSM-III schizophrenia from bipolar and unipolar affective illness and to cross-validate these correlates in an independently ascertained sample of patients with Research Diagnostic Criteria (RDC) schizophrenia or affective disorder. Method: The criterion sample consisted of 83 patients consecutively admitted to a state-operated community mental health center. Diagnoses of schizophrenia; bipolar disorder, manic; and major depression were assigned by using DSM-III. The replication sample consisted of 60 adults with RDC diagnoses of schizophrenia, schizoaffective disorder, bipolar disorder, and unipolar disorder who were parents of children in two samples collected for a study of offspring at high risk for schizophrenia and other psychopathology. After the patients in the criterion sample were classified by logistic regres-sion analysis, the results were used to classify patients in the replication sample. Results: The MMPI indicators had adequate sensitivity, specificity, and predictive power for classifying schizophrenia, and there was a moderately high rate of diagnostic agreement between the MMPI and DSM-III. Cross-validation in the replication sample was successful. Overall, the MMPI index was an adequate inclusion and exclusion criterion not only for DSM-lll-defined but also for RDC-defined schizophrenia. Conclusions: A psychometric index composed of the paranoid schizophrenia, psychoticism, and manifest hostility scales from the MMP/ would be a cost-effective measure to increase diagnostic efficiency in future schizophrenia research and clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=0025796792&partnerID=8YFLogxK
M3 - Article
C2 - 2035718
AN - SCOPUS:0025796792
SN - 0002-953X
VL - 148
SP - 762
EP - 767
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 6
ER -