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Replacing microglia to treat a brain disease
Siling Du
,
Jonathan Kipnis
Division of Immunobiology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
DBBS - Immunology
DBBS - Molecular Cell Biology
DBBS - Molecular Genetics and Genomics
DBBS - Neurosciences
Brain Tumor Center
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Center for Brain Immunology & Glia (BIG)
Hope Center for Neurological Disorders
Research output
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Review article
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peer-review
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Keyphrases
Microglia
100%
Brain Diseases
100%
CSF1R
66%
Axonal Spheroids
66%
Pigmented Glia
66%
Disease Progression
33%
Mouse Model
33%
Immune Response
33%
Central Nervous System
33%
Gene mutation
33%
Replacement Therapy
33%
Homeostasis
33%
Genetic Basis
33%
Neurological Diseases
33%
Therapeutic Strategies
33%
Resident Macrophages
33%
Human Patients
33%
Microglial Development
33%
Microglial Dysfunction
33%
Therapeutic Promises
33%
Adult-onset Leukoencephalopathy with Axonal Spheroids and pigmented Glia
33%
Microgliopathy
33%
Microglial Replacement
33%
Medicine and Dentistry
Microglia
100%
Brain Disease
100%
Glia
100%
Tumor Spheroid
100%
Colony Stimulating Factor 1
66%
Receptor Gene
66%
Immune Response
33%
Macrophage
33%
Leukoencephalopathy
33%
Homeostasis
33%
Gene Mutation
33%
Disease Exacerbation
33%
Disease
33%
Neurologic Disease
33%
Central Nervous System
33%
Substitution Therapy
33%
Immunology and Microbiology
Microglia
100%
Glia
100%
Tumor Spheroid
100%
Colony Stimulating Factor 1 Receptor
66%
Receptor Gene
66%
Wild Type
33%
Homeostasis
33%
Mouse Model
33%
Macrophage
33%
Immune Response
33%
Central Nervous System
33%
Gene Mutation
33%
Neuroscience
Microglia
100%
Glia
100%
Brain Disease
100%
Receptor Gene
66%
Colony Stimulating Factor 1 Receptor
66%
Leukoencephalopathy
33%
Central Nervous System
33%
Macrophage
33%
Nervous System Disorder
33%
Gene Mutation
33%
Pharmacology, Toxicology and Pharmaceutical Science
Receptor
100%
Colony Stimulating Factor 1
100%
Brain Disease
100%
Mouse Model
50%
Replacement Therapy
50%
Disease Exacerbation
50%
Neurologic Disease
50%
Leukoencephalopathy
50%