Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with 18F-Fluorodeoxyglucose in Humans

Tyler J. Fraum; John P. Crandall; Daniel R. Ludwig; Sihao Chen; Kathryn J. Fowler; Richard A. Laforest; Amber Salter; Farrokh Dehdashti; Hongyu An; Richard L. Wahl

doi:10.1016/j.cmet.2019.05.019

Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with ¹⁸F-Fluorodeoxyglucose in Humans

Tyler J. Fraum, John P. Crandall, Daniel R. Ludwig, Sihao Chen, Kathryn J. Fowler, Richard A. Laforest, Amber Salter, Farrokh Dehdashti, Hongyu An, Richard L. Wahl

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Utilizing a test-retest design and a modern cold-activation protocol, Fraum et al. show that BAT volume and SUL_max are relatively stable across imaging sessions. These quantitative BAT metrics, which can be measured by either ¹⁸F-FDG-PET/CT or ¹⁸F-FDG-PET/MRI with excellent inter-reader reliability, are robust for tracking BAT activation longitudinally.

Original language	English
Pages (from-to)	212-224.e4
Journal	Cell metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.05.019
State	Published - Jul 2 2019

Keywords

PET/CT
PET/MRI
brown adipose tissue
repeatability
test-retest

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10.1016/j.cmet.2019.05.019

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title = "Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with 18F-Fluorodeoxyglucose in Humans",

abstract = "Utilizing a test-retest design and a modern cold-activation protocol, Fraum et al. show that BAT volume and SULmax are relatively stable across imaging sessions. These quantitative BAT metrics, which can be measured by either 18F-FDG-PET/CT or 18F-FDG-PET/MRI with excellent inter-reader reliability, are robust for tracking BAT activation longitudinally.",

keywords = "PET/CT, PET/MRI, brown adipose tissue, repeatability, test-retest",

author = "Fraum, {Tyler J.} and Crandall, {John P.} and Ludwig, {Daniel R.} and Sihao Chen and Fowler, {Kathryn J.} and Laforest, {Richard A.} and Amber Salter and Farrokh Dehdashti and Hongyu An and Wahl, {Richard L.}",

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doi = "10.1016/j.cmet.2019.05.019",

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T1 - Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with 18F-Fluorodeoxyglucose in Humans

AU - Fraum, Tyler J.

AU - Crandall, John P.

AU - Ludwig, Daniel R.

AU - Chen, Sihao

AU - Fowler, Kathryn J.

AU - Laforest, Richard A.

AU - Salter, Amber

AU - Dehdashti, Farrokh

AU - An, Hongyu

AU - Wahl, Richard L.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Utilizing a test-retest design and a modern cold-activation protocol, Fraum et al. show that BAT volume and SULmax are relatively stable across imaging sessions. These quantitative BAT metrics, which can be measured by either 18F-FDG-PET/CT or 18F-FDG-PET/MRI with excellent inter-reader reliability, are robust for tracking BAT activation longitudinally.

AB - Utilizing a test-retest design and a modern cold-activation protocol, Fraum et al. show that BAT volume and SULmax are relatively stable across imaging sessions. These quantitative BAT metrics, which can be measured by either 18F-FDG-PET/CT or 18F-FDG-PET/MRI with excellent inter-reader reliability, are robust for tracking BAT activation longitudinally.

KW - PET/CT

KW - PET/MRI

KW - brown adipose tissue

KW - repeatability

KW - test-retest

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DO - 10.1016/j.cmet.2019.05.019

M3 - Article

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AN - SCOPUS:85067960786

SN - 1550-4131

VL - 30

SP - 212-224.e4

JO - Cell metabolism

JF - Cell metabolism

IS - 1

ER -

Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with ¹⁸F-Fluorodeoxyglucose in Humans

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Keywords

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