Abstract
Transplantation of fetal neocortex into the site of trigeminal brainstem injury induces regeneration of trigeminal primary afferent axons in adult rats. Renewed growth of injured primary afferent fibers into donor cortex can be extensive, though the innervation pattern does not resemble that normally seen in either brainstem or somatosensory cortex. Examination of the structural and functional characteristics of individual regenerate axon collaterals suggests that their morphology is determined by both intrinsic and postsynaptic target factors. Marked topographic alterations, however, question the utility of fetal cortical transplantation procedures in effecting functional recovery from brainstem injury.
Original language | English |
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Pages (from-to) | 301-308 |
Number of pages | 8 |
Journal | Developmental Brain Research |
Volume | 32 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1987 |
Externally published | Yes |
Keywords
- Cortex
- Development
- Plasticity
- Regeneration
- Transplantation
- Trigeminal