TY - JOUR
T1 - Renal transplantation and predisposition to opportunistic infections
AU - Dandamudi, Raja
AU - Smith, Jodi
AU - Dharnidharka, Vikas R.
N1 - Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/4
Y1 - 2019/4
N2 - Purpose of review Infections represent a significant source of morbidity and mortality after kidney transplantation in children. We review recent advances in epidemiology, assessment, prevention and treatment for several different infections. Recent findings Infections, such as bacterial urinary tract infection or opportunistic viral infection remain common, may be increasing and represent a large proportion of hospitalization. Extended antiviral agent use reduces the incidence of cytomegalovirus disease but its efficacy to reduce Epstein-Barr virus disease remains controversial. Human herpesvirus-6 and hepatitis E virus represent new infections to keep in mind. Ureteral stenting increases the rate of early UTI. Several new vaccines are now available, but rates of complete vaccination pretransplant are low. Summary Infections remain a critical posttransplant issue associated with significant medical burdens. Emerging data on associated risk factors, assessment of and treatment for infections provide clinicians with new knowledge.
AB - Purpose of review Infections represent a significant source of morbidity and mortality after kidney transplantation in children. We review recent advances in epidemiology, assessment, prevention and treatment for several different infections. Recent findings Infections, such as bacterial urinary tract infection or opportunistic viral infection remain common, may be increasing and represent a large proportion of hospitalization. Extended antiviral agent use reduces the incidence of cytomegalovirus disease but its efficacy to reduce Epstein-Barr virus disease remains controversial. Human herpesvirus-6 and hepatitis E virus represent new infections to keep in mind. Ureteral stenting increases the rate of early UTI. Several new vaccines are now available, but rates of complete vaccination pretransplant are low. Summary Infections remain a critical posttransplant issue associated with significant medical burdens. Emerging data on associated risk factors, assessment of and treatment for infections provide clinicians with new knowledge.
KW - Cytomegalovirus
KW - Epstein-Barr virus
KW - Infections
KW - Kidney transplant
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=85062632457&partnerID=8YFLogxK
U2 - 10.1097/MOP.0000000000000728
DO - 10.1097/MOP.0000000000000728
M3 - Review article
C2 - 30562175
AN - SCOPUS:85062632457
SN - 1040-8703
VL - 31
SP - 226
EP - 231
JO - Current opinion in pediatrics
JF - Current opinion in pediatrics
IS - 2
ER -