Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup

Rupesh Raina, Manpreet K. Grewal, Martha Blackford, Jordan M. Symons, Michael J.G. Somers, Christoph Licht, Rajit K. Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui Kim Yap, Marcelo de Sousa Tavares, Timothy E. Bunchman, Michelle Bestic, Bradley A. Warady, Maria Díaz González de Ferris

Research output: Contribution to journalArticle

Abstract

Background: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). Methods: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. Results and Conclusions: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.

Original languageEnglish
Pages (from-to)2427-2448
Number of pages22
JournalPediatric Nephrology
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • Children
  • Hemodialysis
  • Intoxications
  • Renal replacement therapies

Fingerprint Dive into the research topics of 'Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup'. Together they form a unique fingerprint.

  • Cite this

    Raina, R., Grewal, M. K., Blackford, M., Symons, J. M., Somers, M. J. G., Licht, C., Basu, R. K., Sethi, S. K., Chand, D., Kapur, G., McCulloch, M., Bagga, A., Krishnappa, V., Yap, H. K., de Sousa Tavares, M., Bunchman, T. E., Bestic, M., Warady, B. A., & de Ferris, M. D. G. (2019). Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup. Pediatric Nephrology, 34(11), 2427-2448. https://doi.org/10.1007/s00467-019-04319-2