TY - JOUR
T1 - Renal replacement therapy in the management of intoxications in children
T2 - recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup
AU - Raina, Rupesh
AU - Grewal, Manpreet K.
AU - Blackford, Martha
AU - Symons, Jordan M.
AU - Somers, Michael J.G.
AU - Licht, Christoph
AU - Basu, Rajit K.
AU - Sethi, Sidharth Kumar
AU - Chand, Deepa
AU - Kapur, Gaurav
AU - McCulloch, Mignon
AU - Bagga, Arvind
AU - Krishnappa, Vinod
AU - Yap, Hui Kim
AU - de Sousa Tavares, Marcelo
AU - Bunchman, Timothy E.
AU - Bestic, Michelle
AU - Warady, Bradley A.
AU - de Ferris, Maria Díaz González
N1 - Publisher Copyright:
© 2019, IPNA.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Background: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). Methods: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. Results and Conclusions: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.
AB - Background: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). Methods: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. Results and Conclusions: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.
KW - Children
KW - Hemodialysis
KW - Intoxications
KW - Renal replacement therapies
UR - http://www.scopus.com/inward/record.url?scp=85071451833&partnerID=8YFLogxK
U2 - 10.1007/s00467-019-04319-2
DO - 10.1007/s00467-019-04319-2
M3 - Article
C2 - 31446483
AN - SCOPUS:85071451833
SN - 0931-041X
VL - 34
SP - 2427
EP - 2448
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 11
ER -