TY - JOUR
T1 - Renal Denervation for the Treatment of Hypertension
T2 - A Scientific Statement from the American Heart Association
AU - Cluett, Jennifer L.
AU - Blazek, Olivia
AU - Brown, Angela L.
AU - East, Cara
AU - Ferdinand, Keith C.
AU - Fisher, Naomi D.L.
AU - Ford, Cassandra D.
AU - Griffin, Karen A.
AU - Mena-Hurtado, Carlos I.
AU - Sarathy, Harini
AU - Vongpatanasin, Wanpen
AU - Townsend, Raymond R.
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/10/1
Y1 - 2024/10/1
N2 - Hypertension is a leading risk factor for cardiovascular morbidity and mortality. Despite the widespread availability of both pharmacological and lifestyle therapeutic options, blood pressure control rates across the globe are worsening. In fact, only 23% of individuals with high blood pressure in the United States achieve treatment goals. In 2023, the US Food and Drug Administration approved renal denervation, a catheter-based procedure that ablates the renal sympathetic nerves, as an adjunctive treatment for patients in whom lifestyle modifications and antihypertensive medications do not adequately control blood pressure. This approval followed the publication of multiple randomized clinical studies using rigorous trial designs, all incorporating renal angiogram as the sham control. Most but not all of the new generation of trials reached their primary end point, demonstrating modest efficacy of renal denervation in lowering blood pressure across a spectrum of hypertension, from mild to truly resistant. Individual patient responses vary, and further research is needed to identify those who may benefit most. The initial safety profile appears favorable, and multiple ongoing studies are assessing longer-term efficacy and safety. Multidisciplinary teams that include hypertension specialists and adequately trained proceduralists are crucial to ensure that referrals are made appropriately with full consideration of the potential risks and benefits. Incorporating patient preferences and engaging in shared decision-making conversations will help patients make the best decisions given their individual circumstances. Although further research is clearly needed, renal denervation presents a novel treatment strategy for patients with uncontrolled blood pressure.
AB - Hypertension is a leading risk factor for cardiovascular morbidity and mortality. Despite the widespread availability of both pharmacological and lifestyle therapeutic options, blood pressure control rates across the globe are worsening. In fact, only 23% of individuals with high blood pressure in the United States achieve treatment goals. In 2023, the US Food and Drug Administration approved renal denervation, a catheter-based procedure that ablates the renal sympathetic nerves, as an adjunctive treatment for patients in whom lifestyle modifications and antihypertensive medications do not adequately control blood pressure. This approval followed the publication of multiple randomized clinical studies using rigorous trial designs, all incorporating renal angiogram as the sham control. Most but not all of the new generation of trials reached their primary end point, demonstrating modest efficacy of renal denervation in lowering blood pressure across a spectrum of hypertension, from mild to truly resistant. Individual patient responses vary, and further research is needed to identify those who may benefit most. The initial safety profile appears favorable, and multiple ongoing studies are assessing longer-term efficacy and safety. Multidisciplinary teams that include hypertension specialists and adequately trained proceduralists are crucial to ensure that referrals are made appropriately with full consideration of the potential risks and benefits. Incorporating patient preferences and engaging in shared decision-making conversations will help patients make the best decisions given their individual circumstances. Although further research is clearly needed, renal denervation presents a novel treatment strategy for patients with uncontrolled blood pressure.
KW - AHA Scientific Statements
KW - blood pressure
KW - catheters
KW - denervation
KW - hypertension
KW - kidney
KW - patient care team
UR - http://www.scopus.com/inward/record.url?scp=85200715456&partnerID=8YFLogxK
U2 - 10.1161/HYP.0000000000000240
DO - 10.1161/HYP.0000000000000240
M3 - Review article
C2 - 39101202
AN - SCOPUS:85200715456
SN - 0194-911X
VL - 81
SP - e135-e148
JO - Hypertension
JF - Hypertension
IS - 10
ER -