TY - JOUR
T1 - Renal concentrations of prostaglandin E in acute and chronic renal ischemia
AU - Jaffe, Bernard M.
AU - Parker, Charles W.
AU - Marshall, Garland R.
AU - Needleman, Philip
N1 - Funding Information:
*Supported in part by NIH Training Grants 371, NIH Research Grants HE-14397-01, HE-14509-01 and ~104646, and Grant 68-115, 70-762 and 70-111 from the American Heart Association.
PY - 1972/11/1
Y1 - 1972/11/1
N2 - We have applied a radioimmunoassay for prostaglandins to the measurement of PGE in renal tissue and serum in models of renal hypertension in rats. Chronic renal-induced hypertension causes increased concentrations of PGE in the ischemic kidney and elevated serum levels of PGE. Acute renal clamp models also result in increased PGE concentrations in the clamped kidney, but inhibition of prostaglandin synthesis by indomethacin treatment does not influence the frequency of hypertensive responses following release of the clamps.
AB - We have applied a radioimmunoassay for prostaglandins to the measurement of PGE in renal tissue and serum in models of renal hypertension in rats. Chronic renal-induced hypertension causes increased concentrations of PGE in the ischemic kidney and elevated serum levels of PGE. Acute renal clamp models also result in increased PGE concentrations in the clamped kidney, but inhibition of prostaglandin synthesis by indomethacin treatment does not influence the frequency of hypertensive responses following release of the clamps.
UR - http://www.scopus.com/inward/record.url?scp=0015426724&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(72)90481-0
DO - 10.1016/0006-291X(72)90481-0
M3 - Article
C2 - 4638755
AN - SCOPUS:0015426724
VL - 49
SP - 799
EP - 805
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -