Renal concentrations of prostaglandin E in acute and chronic renal ischemia

Bernard M. Jaffe, Charles W. Parker, Garland R. Marshall, Philip Needleman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We have applied a radioimmunoassay for prostaglandins to the measurement of PGE in renal tissue and serum in models of renal hypertension in rats. Chronic renal-induced hypertension causes increased concentrations of PGE in the ischemic kidney and elevated serum levels of PGE. Acute renal clamp models also result in increased PGE concentrations in the clamped kidney, but inhibition of prostaglandin synthesis by indomethacin treatment does not influence the frequency of hypertensive responses following release of the clamps.

Original languageEnglish
Pages (from-to)799-805
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume49
Issue number3
DOIs
StatePublished - Nov 1 1972

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