Renal complications of immune checkpoint blockade

Naoka Murakami; Shveta Motwani; Leonardo V. Riella

doi:10.1016/j.currproblcancer.2016.12.004

Renal complications of immune checkpoint blockade

Naoka Murakami, Shveta Motwani, Leonardo V. Riella

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

Immune checkpoint inhibitors have been approved for a variety of cancer species. Renal complications in use of these agents are not very common compared with other immune-related adverse events (irAE). However, it is crucial for physicians to recognize and manage renal manifestations of irAE. In this review, we will summarize the up-to-date knowledge of the clinical presentation, pathologic features, and management of renal irAE. In addition, we will discuss the safety of immune checkpoint inhibitors in patients with chronic kidney disease as well as in kidney transplant recipients.

Original language	English
Pages (from-to)	100-110
Number of pages	11
Journal	Current Problems in Cancer
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.currproblcancer.2016.12.004
State	Published - Mar 2017

Keywords

acute kidney injury
chronic kidney injury
CTLA-4
Immune check point inhibitor
PD-1
transplant

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10.1016/j.currproblcancer.2016.12.004

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title = "Renal complications of immune checkpoint blockade",

abstract = "Immune checkpoint inhibitors have been approved for a variety of cancer species. Renal complications in use of these agents are not very common compared with other immune-related adverse events (irAE). However, it is crucial for physicians to recognize and manage renal manifestations of irAE. In this review, we will summarize the up-to-date knowledge of the clinical presentation, pathologic features, and management of renal irAE. In addition, we will discuss the safety of immune checkpoint inhibitors in patients with chronic kidney disease as well as in kidney transplant recipients.",

keywords = "acute kidney injury, chronic kidney injury, CTLA-4, Immune check point inhibitor, PD-1, transplant",

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AU - Motwani, Shveta

AU - Riella, Leonardo V.

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N2 - Immune checkpoint inhibitors have been approved for a variety of cancer species. Renal complications in use of these agents are not very common compared with other immune-related adverse events (irAE). However, it is crucial for physicians to recognize and manage renal manifestations of irAE. In this review, we will summarize the up-to-date knowledge of the clinical presentation, pathologic features, and management of renal irAE. In addition, we will discuss the safety of immune checkpoint inhibitors in patients with chronic kidney disease as well as in kidney transplant recipients.

AB - Immune checkpoint inhibitors have been approved for a variety of cancer species. Renal complications in use of these agents are not very common compared with other immune-related adverse events (irAE). However, it is crucial for physicians to recognize and manage renal manifestations of irAE. In this review, we will summarize the up-to-date knowledge of the clinical presentation, pathologic features, and management of renal irAE. In addition, we will discuss the safety of immune checkpoint inhibitors in patients with chronic kidney disease as well as in kidney transplant recipients.

KW - acute kidney injury

KW - chronic kidney injury

KW - CTLA-4

KW - Immune check point inhibitor

KW - PD-1

KW - transplant

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VL - 41

SP - 100

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JO - Current Problems in Cancer

JF - Current Problems in Cancer

IS - 2

ER -

Renal complications of immune checkpoint blockade

Abstract

Keywords

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