Abstract
We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle–cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single-cell activities without the need of complex magnetic manipulation devices.
| Original language | English |
|---|---|
| Pages (from-to) | 7384-7387 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 55 |
| Issue number | 26 |
| DOIs | |
| State | Published - Jun 20 2016 |
Keywords
- colloids
- immunology
- Janus particles
- magnetic properties
- nanotechnology