Remodeling of yeast genome expression in response to environmental changes

H. C. Causton, B. Ren, Seok Koh Sang Seok Koh, C. T. Harbison, E. Kanin, E. G. Jennings, Ihn Lee Tong Ihn Lee, H. L. True, E. S. Lander, R. A. Young

Research output: Contribution to journalArticle

995 Scopus citations

Abstract

We used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular environment, including changes in temperature, oxidation, nutrients, pH, and osmolarity. The results demonstrate that more than half of the genome is involved in various responses to environmental change and identify the global set of genes induced and repressed by each condition. These data implicate a substantial number of previously uncharacterized genes in these responses and reveal a signature common to environmental responses that involves ∼10% of yeast genes. The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change. These results provide a global description of the transcriptional response to environmental change and extend our understanding of the role of activators in effecting this response.

Original languageEnglish
Pages (from-to)323-337
Number of pages15
JournalMolecular biology of the cell
Volume12
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint Dive into the research topics of 'Remodeling of yeast genome expression in response to environmental changes'. Together they form a unique fingerprint.

  • Cite this

    Causton, H. C., Ren, B., Sang Seok Koh, S. K., Harbison, C. T., Kanin, E., Jennings, E. G., Tong Ihn Lee, I. L., True, H. L., Lander, E. S., & Young, R. A. (2001). Remodeling of yeast genome expression in response to environmental changes. Molecular biology of the cell, 12(2), 323-337. https://doi.org/10.1091/mbc.12.2.323