Reluctant vesicles coaxed into the limelight

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Synapses respond to brief, repetitive stimulation with synaptic depression when initial transmitter release probability is high. Vesicle depletion has been a long-standing hypothesis for depression, but results unexplained by the depletion hypothesis have been nagging. In this issue of Neuron, Xu and Wu show that, under some conditions, calcium current inactivation explains stimulus-dependent depression at the calyx of Held.

Original languageEnglish
Pages (from-to)523-525
Number of pages3
Issue number4
StatePublished - May 19 2005

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