TY - JOUR
T1 - Relief of idiopathic subjective tinnitus
T2 - Is gabapentin effective?
AU - Piccirillo, Jay F.
AU - Finnell, Joshua
AU - Vlahiotis, Anna
AU - Chole, Richard A.
AU - Spitznagel, Edward
PY - 2007/4
Y1 - 2007/4
N2 - Objective: To assess the therapeutic benefit of gabapentin (Neurontin) for subjective idiopathic troublesome tinnitus. Design: An 8-week, double-blind, randomized clinical trial. Setting: Academic otolaryngology clinic in St Louis, Mo. Subjects: One hundred thirty-five subjects with severe idiopathic subjective tinnitus of 6 months' duration or longer. Intervention: Gabapentin, at a maintenance dosage of 900 to 3600 mg/d for 8 weeks, or lactose placebo. Main Outcome Measure: Change in the Tinnitus Handicap Inventory score from baseline to the study end point. Results: The overall change in the Tinnitus Handicap Inventory score for the entire cohort from baseline to week 8 was 11.2; the change among the 59 subjects randomized to the gabapentin arm was 11.3 and the change among the 56 subjects in the placebo arm was 11.0. The difference was 0.03 (95% confidence interval, ?5.5 to 6.2; P=.91). Conclusion: Gabapentin is no more effective than placebo for the relief of idiopathic subjective tinnitus. Trial Registration: clinicaltrials.gov Identifier: NCT00317850
AB - Objective: To assess the therapeutic benefit of gabapentin (Neurontin) for subjective idiopathic troublesome tinnitus. Design: An 8-week, double-blind, randomized clinical trial. Setting: Academic otolaryngology clinic in St Louis, Mo. Subjects: One hundred thirty-five subjects with severe idiopathic subjective tinnitus of 6 months' duration or longer. Intervention: Gabapentin, at a maintenance dosage of 900 to 3600 mg/d for 8 weeks, or lactose placebo. Main Outcome Measure: Change in the Tinnitus Handicap Inventory score from baseline to the study end point. Results: The overall change in the Tinnitus Handicap Inventory score for the entire cohort from baseline to week 8 was 11.2; the change among the 59 subjects randomized to the gabapentin arm was 11.3 and the change among the 56 subjects in the placebo arm was 11.0. The difference was 0.03 (95% confidence interval, ?5.5 to 6.2; P=.91). Conclusion: Gabapentin is no more effective than placebo for the relief of idiopathic subjective tinnitus. Trial Registration: clinicaltrials.gov Identifier: NCT00317850
UR - http://www.scopus.com/inward/record.url?scp=34247372983&partnerID=8YFLogxK
U2 - 10.1001/archotol.133.4.390
DO - 10.1001/archotol.133.4.390
M3 - Article
C2 - 17438255
AN - SCOPUS:34247372983
SN - 0886-4470
VL - 133
SP - 390
EP - 397
JO - Archives of Otolaryngology - Head and Neck Surgery
JF - Archives of Otolaryngology - Head and Neck Surgery
IS - 4
ER -