Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure

Nobuo Katsube; David Schwartz; Philip Needleman

doi:10.1016/0006-291X(85)91226-4

Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure

Nobuo Katsube, David Schwartz, Philip Needleman

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic blood pressure; b) right atrial pressure; c) left ventricular end diastolic pressure; and d) plasma atriopeptin immunoreactivity. While continuous infusion of angiotensin II also produced a sustained elevation in left ventricular end diastolic pressure, the changes in right atrial pressure and plasma atriopeptin were only transient. These data suggest that plasma atriopeptin most closely correlates with right atrial pressure. Consistent with this hypothesis, we found that the release of atriopeptin directly correlated with changes in right atrial pressure in anesthetized, water-immersed rats.

Original language	English
Pages (from-to)	937-944
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	133
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(85)91226-4
State	Published - Dec 31 1985

Access to Document

10.1016/0006-291X(85)91226-4

Cite this

@article{549b9647c7844cd5a383a8eadba559dc,

title = "Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure",

abstract = "Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic blood pressure; b) right atrial pressure; c) left ventricular end diastolic pressure; and d) plasma atriopeptin immunoreactivity. While continuous infusion of angiotensin II also produced a sustained elevation in left ventricular end diastolic pressure, the changes in right atrial pressure and plasma atriopeptin were only transient. These data suggest that plasma atriopeptin most closely correlates with right atrial pressure. Consistent with this hypothesis, we found that the release of atriopeptin directly correlated with changes in right atrial pressure in anesthetized, water-immersed rats.",

author = "Nobuo Katsube and David Schwartz and Philip Needleman",

year = "1985",

month = dec,

day = "31",

doi = "10.1016/0006-291X(85)91226-4",

language = "English",

volume = "133",

pages = "937--944",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

number = "3",

}

TY - JOUR

T1 - Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure

AU - Katsube, Nobuo

AU - Schwartz, David

AU - Needleman, Philip

PY - 1985/12/31

Y1 - 1985/12/31

N2 - Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic blood pressure; b) right atrial pressure; c) left ventricular end diastolic pressure; and d) plasma atriopeptin immunoreactivity. While continuous infusion of angiotensin II also produced a sustained elevation in left ventricular end diastolic pressure, the changes in right atrial pressure and plasma atriopeptin were only transient. These data suggest that plasma atriopeptin most closely correlates with right atrial pressure. Consistent with this hypothesis, we found that the release of atriopeptin directly correlated with changes in right atrial pressure in anesthetized, water-immersed rats.

AB - Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic blood pressure; b) right atrial pressure; c) left ventricular end diastolic pressure; and d) plasma atriopeptin immunoreactivity. While continuous infusion of angiotensin II also produced a sustained elevation in left ventricular end diastolic pressure, the changes in right atrial pressure and plasma atriopeptin were only transient. These data suggest that plasma atriopeptin most closely correlates with right atrial pressure. Consistent with this hypothesis, we found that the release of atriopeptin directly correlated with changes in right atrial pressure in anesthetized, water-immersed rats.

UR - http://www.scopus.com/inward/record.url?scp=0022302439&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(85)91226-4

DO - 10.1016/0006-291X(85)91226-4

M3 - Article

C2 - 2935154

AN - SCOPUS:0022302439

SN - 0006-291X

VL - 133

SP - 937

EP - 944

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure

Abstract

Access to Document

Other files and links

Fingerprint

Cite this