TY - GEN
T1 - Relative prolongation of the terminal part of the QT segment is associated with sudden death in the elderly
AU - Lee, D. W.
AU - Stein, Phyllis K.
AU - Lundequam, E. J.
AU - Sotoodehnia, N.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Holter-based QT parameters were measured in 40 matched participants (age 73.03 ± 4.51, 24 M, 8 F), 20 with SCD (sudden cardiac death) and 20 without SCD who had recordings in the Cardiovascular Health Study. Time to SCD was 6.5±2.8 years. Beat-by-beat QTonset, QTpeak, and QTend times were measured and averaged for one 2-min segment/hr and results compared between cases and controls. QT interval was significantly longer among cases (445 ± 88 vs. 405 ± 45 ms, p<0.001). Correcting the QT for heart rate did not affect this relationship. % QT in the pre-peak interval was significantly shorter in SCD cases (23.7 ± 3.1% vs. 24.2 ± 3.7%, p=0.040). % QT in the post-peak interval was significantly longer in SCD cases (23.4 ± 3.9% vs. 22.0 ± 2.5%, p<0.001). Results did not differ by the channel examined. Findings are consistent with a prolonged Holter-based QT and an additional relative prolongation of the terminal QT, in older adults with SCD.
AB - Holter-based QT parameters were measured in 40 matched participants (age 73.03 ± 4.51, 24 M, 8 F), 20 with SCD (sudden cardiac death) and 20 without SCD who had recordings in the Cardiovascular Health Study. Time to SCD was 6.5±2.8 years. Beat-by-beat QTonset, QTpeak, and QTend times were measured and averaged for one 2-min segment/hr and results compared between cases and controls. QT interval was significantly longer among cases (445 ± 88 vs. 405 ± 45 ms, p<0.001). Correcting the QT for heart rate did not affect this relationship. % QT in the pre-peak interval was significantly shorter in SCD cases (23.7 ± 3.1% vs. 24.2 ± 3.7%, p=0.040). % QT in the post-peak interval was significantly longer in SCD cases (23.4 ± 3.9% vs. 22.0 ± 2.5%, p<0.001). Results did not differ by the channel examined. Findings are consistent with a prolonged Holter-based QT and an additional relative prolongation of the terminal QT, in older adults with SCD.
UR - https://www.scopus.com/pages/publications/77952713365
M3 - Conference contribution
AN - SCOPUS:77952713365
SN - 9781424472819
T3 - Computers in Cardiology
SP - 317
EP - 320
BT - Computers in Cardiology 2009, CinC 2009
T2 - 36th Annual Conference of Computers in Cardiology, CinC 2009
Y2 - 13 September 2009 through 16 September 2009
ER -