TY - JOUR
T1 - Relationships between correlated spikes, oxygen and LFP in the resting-state primate
AU - Li, Jingfeng M.
AU - Acland, Benjamin T.
AU - Brenner, Alexander S.
AU - Bentley, William J.
AU - Snyder, Lawrence H.
N1 - Publisher Copyright:
© 2021
PY - 2022/2/15
Y1 - 2022/2/15
N2 - Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simultaneously recorded oxygen level, spikes, and local field potential (LFP) at multiple sites in awake, resting monkeys. Following a spike, the average local oxygen and LFP voltage responses each resemble a task-driven BOLD response, with LFP preceding oxygen by 0.5 s. Between sites, features of the long-range correlation patterns of oxygen, LFP, and spikes are similar to features seen in rsfMRI. Most of the variance shared between sites lies in the infraslow frequency band (0.01–0.1 Hz) and in the infraslow envelope of higher-frequency bands (e.g. gamma LFP). While gamma LFP and infraslow LFP are both strong correlates of local oxygen, infraslow LFP explains significantly more of the variance shared between correlated oxygen signals than any other electrophysiological signal. Together these findings are consistent with a causal relationship between infraslow LFP and long-range oxygen correlations in the resting state.
AB - Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simultaneously recorded oxygen level, spikes, and local field potential (LFP) at multiple sites in awake, resting monkeys. Following a spike, the average local oxygen and LFP voltage responses each resemble a task-driven BOLD response, with LFP preceding oxygen by 0.5 s. Between sites, features of the long-range correlation patterns of oxygen, LFP, and spikes are similar to features seen in rsfMRI. Most of the variance shared between sites lies in the infraslow frequency band (0.01–0.1 Hz) and in the infraslow envelope of higher-frequency bands (e.g. gamma LFP). While gamma LFP and infraslow LFP are both strong correlates of local oxygen, infraslow LFP explains significantly more of the variance shared between correlated oxygen signals than any other electrophysiological signal. Together these findings are consistent with a causal relationship between infraslow LFP and long-range oxygen correlations in the resting state.
KW - Default mode network
KW - Functional connectivity
KW - Magnetic resonance imaging
KW - Neurohemodynamic coupling
KW - Oxygen polarography
UR - http://www.scopus.com/inward/record.url?scp=85121508639&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2021.118728
DO - 10.1016/j.neuroimage.2021.118728
M3 - Article
C2 - 34923136
AN - SCOPUS:85121508639
SN - 1053-8119
VL - 247
JO - NeuroImage
JF - NeuroImage
M1 - 118728
ER -