TY - JOUR
T1 - Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity
AU - Dolatshahi, Mahsa
AU - Commean, Paul K.
AU - Rahmani, Farzaneh
AU - Xu, Yifei
AU - Liu, Jingxia
AU - Hosseinzadeh Kassani, Sara
AU - Naghashzadeh, Mahshid
AU - Lloyd, La Kisha
AU - Nguyen, Caitlyn
AU - McBee Kemper, Abby
AU - Hantler, Nancy
AU - Ly, Maria
AU - Yu, Gary
AU - Flores, Shaney
AU - Ippolito, Joseph E.
AU - Song, Sheng Kwei
AU - Sirlin, Claude B.
AU - Dai, Weiying
AU - Mittendorfer, Bettina
AU - Morris, John C.
AU - Benzinger, Tammie L.S.
AU - Raji, Cyrus A.
N1 - Publisher Copyright:
© 2024 The Author(s). Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2025/1
Y1 - 2025/1
N2 - Objective: This study investigated how obesity, BMI ≥ 30 kg/m2, abdominal adiposity, and systemic inflammation relate to neuroinflammation using diffusion basis spectrum imaging. Methods: We analyzed data from 98 cognitively normal midlife participants (mean age: 49.4 [SD 6.2] years; 34 males [34.7%]; 56 with obesity [57.1%]). Participants underwent brain and abdominal magnetic resonance imaging (MRI), blood tests, and amyloid positron emission tomography (PET) imaging. Abdominal visceral and subcutaneous adipose tissue (VAT and SAT, respectively) was segmented, and Centiloids were calculated. Diffusion basis spectrum imaging parameter maps were created using an in-house script, and tract-based spatial statistics assessed white matter differences in high versus low BMI values, VAT, SAT, insulin resistance, systemic inflammation, and Centiloids, with age and sex as covariates. Results: Obesity, high VAT, and high SAT were linked to lower axial diffusivity, reduced fiber fraction, and increased restricted fraction in white matter. Obesity was additionally associated with higher hindered fraction and lower fractional anisotropy. Also, individuals with high C-reactive protein showed lower axial diffusivity. Higher restricted fraction correlated with continuous BMI and SAT particularly in male individuals, whereas VAT effects were similar in male and female individuals. Conclusions: The findings suggest that, at midlife, obesity and abdominal fat are associated with reduced brain axonal density and increased inflammation, with visceral fat playing a significant role in both sexes. (Figure presented.).
AB - Objective: This study investigated how obesity, BMI ≥ 30 kg/m2, abdominal adiposity, and systemic inflammation relate to neuroinflammation using diffusion basis spectrum imaging. Methods: We analyzed data from 98 cognitively normal midlife participants (mean age: 49.4 [SD 6.2] years; 34 males [34.7%]; 56 with obesity [57.1%]). Participants underwent brain and abdominal magnetic resonance imaging (MRI), blood tests, and amyloid positron emission tomography (PET) imaging. Abdominal visceral and subcutaneous adipose tissue (VAT and SAT, respectively) was segmented, and Centiloids were calculated. Diffusion basis spectrum imaging parameter maps were created using an in-house script, and tract-based spatial statistics assessed white matter differences in high versus low BMI values, VAT, SAT, insulin resistance, systemic inflammation, and Centiloids, with age and sex as covariates. Results: Obesity, high VAT, and high SAT were linked to lower axial diffusivity, reduced fiber fraction, and increased restricted fraction in white matter. Obesity was additionally associated with higher hindered fraction and lower fractional anisotropy. Also, individuals with high C-reactive protein showed lower axial diffusivity. Higher restricted fraction correlated with continuous BMI and SAT particularly in male individuals, whereas VAT effects were similar in male and female individuals. Conclusions: The findings suggest that, at midlife, obesity and abdominal fat are associated with reduced brain axonal density and increased inflammation, with visceral fat playing a significant role in both sexes. (Figure presented.).
UR - http://www.scopus.com/inward/record.url?scp=85208532873&partnerID=8YFLogxK
U2 - 10.1002/oby.24188
DO - 10.1002/oby.24188
M3 - Article
C2 - 39517107
AN - SCOPUS:85208532873
SN - 1930-7381
VL - 33
SP - 41
EP - 53
JO - Obesity
JF - Obesity
IS - 1
ER -