Relationship of the third and fourth heart sounds to transmitral flow

Abigail Manson, Sandor J. Kovacs, Andrew F. Hall, Scott Nudelman

Research output: Contribution to journalConference articlepeer-review

Abstract

The third and fourth heart sounds in humans (S3 and S4) are believed to be caused by vibration of the ventricle and surrounding structures powered by the deceleration of transmitral blood flow during diastole. We modelled the kinematics of heart sound generation using a forced, damped, nonlinear harmonic oscillator with time-dependent stiffness. The oscillator's forcing term utilized the deceleration portion of the clinical Doppler transmitral E (early) and A (atrial) wave. The model's predictions are: 1) an S3 and S4 should always be present, 2) the higher the E and A wave deceleration, the more likely an S3 or S4 is audible, 3) a sufficient deceleration rate and coupling to the oscillator is required for audibility. Model based image processing and estimation theory permitted comparison to simultaneous transmitral Doppler and phonocardiographic data from patients with an without audible S3's and S4's and showed excellent agreement.

Original languageEnglish
Pages (from-to)95-96
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 1
StatePublished - Dec 1 1994
Externally publishedYes
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: Nov 3 1994Nov 6 1994

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